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Cited by 190High Altitude and HypoxiaPulmonary Hypertension Research and TreatmentsHeart Rate Variability and Autonomic Control

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The autonomic nervous system at high altitude.

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Hainsworth, Roger, Drinkhill, Mark J., Rivera-Chira, Maria·2007·Clinical Autonomic Research
DOI 10.1007/s10286-006-0395-7PMC PMC1797062
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Abstract

The effects of hypobaric hypoxia in visitors depend not only on the actual elevation but also on the rate of ascent. Sympathetic activity increases and there are increases in blood pressure and heart rate. Pulmonary vasoconstriction leads to pulmonary hypertension, particularly during exercise. The sympathetic excitation results from hypoxia, partly through chemoreceptor reflexes and partly through altered baroreceptor function. High pulmonary arterial pressures may also cause reflex systemic vasoconstriction. Most permanent high altitude dwellers show excellent adaptation although there are differences between populations in the extent of the ventilatory drive and the erythropoiesis. Some altitude dwellers, particularly Andeans, may develop chronic mountain sickness, the most prominent characteristic of which being excessive polycythaemia. Excessive hypoxia due to peripheral chemoreceptor dysfunction has been suggested as a cause. The hyperviscous blood leads to pulmonary hypertension, symptoms of cerebral hypoperfusion, and eventually right heart failure and death.

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Metadata

Authors
Hainsworth, R., Drinkhill, M. J., & Rivera-Chira, M.
Affiliations
University of Leeds (GB)
Corresponding author
Hainsworth, Roger
ORCID
Drinkhill, Mark J.
Venue
Clinical Autonomic Research
Publisher
Springer Science and Business Media LLC
Published
2007-01-30
Volume
17
Issue
1
Pages
13-19
ISSN
  • 0959-9851 (ISSN-L)
  • 1619-1560
DOI
10.1007/s10286-006-0395-7
PMC
PMC1797062
OpenAlex
W2089866557
Cited by
190
References
0
Citations by year
2026: 11 · 2025: 9 · 2024: 14 · 2023: 11 · 2022: 8 · 2021: 14 · 2020: 5 · 2019: 6 · 2018: 14 · 2017: 13 · 2016: 10 · 2015: 9 · 2014: 17 · 2013: 8 · 2012: 7
FWCI
5.20
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Autonomic Research (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › High Altitude and Hypoxia
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
autonomic nervous system, high altitude, hypobaric hypoxia, sympathetic activity, pulmonary vasoconstriction, pulmonary hypertension, chemoreceptor reflex, baroreceptor function, systemic vasoconstriction, high-altitude adaptation, chronic mountain sickness, polycythemia, erythropoiesis, Andean peoples, right heart failure, cerebral hypoperfusion
MeSH terms
Adaptation, Physiological, Altitude, Altitude Sickness, Animals, Autonomic Nervous System, Cardiovascular Physiological Phenomena, Humans, Travel

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