CoChat
Sign Up
Cited by 7Heart Rate Variability and Autonomic ControlNon-Invasive Vital Sign MonitoringECG Monitoring and Analysis

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Reproducibility of 24-h heart rate variability in children

Bjelakovic, Bojko, Ilic, Dragana, Lukic, Stevo, Vukomanovic, Vladislav, Zarko, Cojbasic, Stankovic, Zoran, Marko, Jovic·2017·Clinical Autonomic Research
DOI 10.1007/s10286-017-0445-3
Open this paper in CoChat — free account

Abstract

Background Over the last decades, time domain heart rate (HR) variability analysis has been explored in different pediatric clinical settings to obtain information on the cardiac autonomic tone. However, the consistency over time of 24 h time domain HRV measurements in children is not well-known. Methods We investigated the reproducibility of 24 h HRV time-domain indices (1 day apart), from 39 healthy children (9.5 ± 5.3 years, 56.4% girls). The parameters analysed included: standard deviation of all the adjacent NN intervals, standard deviation of the averages of NN intervals (the intervals between normal R-peaks) in all 5-min segments, and square root of the mean of the sum of the squares of the differences between adjacent NN intervals, uncorrected and corrected for HR. Reproducibility between two 24-h ECG recordings was evaluated by intraclass correlation coefficients, standard error of measurement, coefficients of variation and Bland-Altman plots. Results For the analyzed time-domain indices, standard deviation of all the adjacent NN intervals corrected for HR showed best reproducibility with the highest intraclass correlation coefficient (0.987), the lowest coefficients of variation (5.5%) and the best level of agreement between two recordings as assessed by Bland-Altman plots. Conclusions Our results indicate that the standard deviation of all the adjacent NN intervals corrected for the HR parameter obtained from 24-h ambulatory recordings in children is consistent and…

Overview

Integrity signals

Registry

Crossref · 10.1007/s10286-017-0445-3

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 1 references

Research works printed but not linked: 32

  1. Malik M, Huikuri H, Lombardi F, Schmidt G (2017) The purpose of heart rate variability measurements. Clin Auton Res 27(3):1–2. doi: 10.1007/s10286-017-0416-8 · DOI
  2. Stys A, Stys T (1998) Current clinical applications of heart rate variability. Clin Cardiol 21(10):719–724 · DOI
  3. Camm AJ, Malik M, Bigger JT, Breithardt G, Cerutti S, Cohen RJ, Coumel P, Fallen EL, Kennedy HL, Kleiger RE, Lombardi F (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93(5):1043–1065 · DOI · Paper page
  4. Winsley RJ, Armstrong N, Bywater K, Fawkner SG (2003) Reliability of heart rate variability measures at rest and during light exercise in children. Br J Sports Med 37(6):550–552 · DOI
  5. Maestri R, Raczak G, Danilowicz- Szymanowicz L et al (2010) Reliability of heart rate variability measurements in patients with a history of myocardial infarction. Clin Sci (Lond) 118(3):195–201 · DOI
  6. Kowalewski MA, Urban M (2004) Short- and long-term reproducibility of autonomic measures in supine and standing positions. Clin Sci (Lond) 106(1):61–66. doi: 10.1042/CS20030119 · DOI
  7. Kazuma N, Otsuka K (2001) Seasonal variation in 1/f fluctuations of heart rate in asthmatic children. Biomed Pharmacother 55(Suppl 1):102s–105s
  8. Prinz F, Schlange T, Asadullah K (2011) Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov 10(9):712. doi: 10.1038/nrd3439-c1 · DOI · Paper page
  9. Pinna GD, Maestri R, Torunski A et al (2007) Heart rate variability measures: a fresh look at reliability. Clin Sci (Lond) 113(3):131–140. doi: 10.1042/CS20070055 · DOI
  10. Schroeder EB, Whitsel EA, Evans GW, Prineas RJ, Chambless LE, Heiss G (2004) Repeatability of heart rate variability measures. J Electrocardiol 37(3):163–172 · DOI
  11. Bjelakovic B, Ilic S, Dimitrijevic L et al (2010) Heart rate variability in infants with central coordination disturbance. Early Hum Dev 86:77–81. doi: 10.1016/j.earlhumdev.2010.01.022 · DOI
  12. McNarry MA, Mackintosh KA (2016) Reproducibility of heart rate variability indices in children with cystic fibrosis. PLoS ONE 11(3):e0151464. doi: 10.1371/journal.pone.0151464 · DOI
  13. Leicht AS, Allen GD (2008) Moderate-term reproducibility of heart rate variability during rest and light to moderate exercise in children. Braz J Med Biol Res 41(5):627–633. doi: 10.1590/S0100-879X2008000700013 · DOI
  14. Dietrich A, Rosmalen JGM, Althaus M et al (2010) Reproducibility of heart rate variability and baroreflex sensitivity measurements in children. Biol Psychol 85(1):71–78. doi: 10.1016/j.biopsycho.2010.05.005 · DOI
  15. Longin E, Dimitriadis C, Shazi S, Gerstner T, Lenz T, König S (2009) Autonomic nervous system function in infants and adolescents: impact of autonomic tests on heart rate variability. Pediatr Cardiol 30(3):311–324. doi: 10.1007/s00246-008-9327-8 · DOI
  16. Lammers AE, Munnery E, Hislop AA, Haworth SG (2010) Heart rate variability predicts outcome in children with pulmonary arterial hypertension. Int J Cardiol 142(2):159–165. doi: 10.1016/j.ijcard.2008.12.087 · DOI
  17. Harnod T, Yang CCH, Hsin Y-L, Shieh K-R, Wang P-J, Kuo TBJ (2008) Heart rate variability in children with refractory generalized epilepsy. Seizure 17(4):297–301. doi: 10.1016/j.seizure.2007.09.002 · DOI
  18. Rakow A, Katz-Salamon M, Ericson M, Edner A, Vanpée M (2013) Decreased heart rate variability in children born with low birth weight. Pediatr Res 74(3):339–343. doi: 10.1038/pr.2013.97 · DOI
  19. Tanaka H (2007) Autonomic function and child chronic fatigue syndrome. Nihon Rinsho 65(6):1105–1112
  20. Fortrat J-O (2002) Inaccurate normal values of heart rate variability spectral analysis in newborn infants. Am J Cardiol 90(3):346 · DOI
  21. Sacha J, Sobon J, Sacha K, Barabach S (2013) Heart rate impact on the reproducibility of heart rate variability analysis. Int J Cardiol 168(4):4257–4259. doi: 10.1016/j.ijcard.2013.04.160 · DOI
  22. Sacha J (2014) Interaction between heart rate and heart rate variability. Ann Noninvasive Electrocardiol 19(3):207–216. doi: 10.1111/anec.12148 · DOI
  23. Gąsior JS, Sacha J, Jeleń PJ, Zieliński J, Przybylski J (2016) Heart rate and respiratory rate influence on heart rate variability repeatability: effects of the correction for the prevailing heart rate. Front Physiol 7:356. doi: 10.3389/fphys.2016.00356 · DOI
  24. Iellamo F, Legramante JM, Raimondi G, Castrucci F, Massaro M, Peruzzi G (1996) Evaluation of reproducibility of spontaneous baroreflex sensitivity at rest and during laboratory tests. J Hypertens 14(9):1099–1104 · DOI
  25. Bland JM, Altman DG (2012) Agreed statistics: measurement method comparison. Anesthesiology 116(1):182–185. doi: 10.1097/ALN.0b013e31823d7784 · DOI
  26. Atkinson G, Nevill AM (1998) Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. Sports Med 26(4):217–238 · DOI
  27. Kleiger RE, Bigger JT, Bosner MS et al (1991) Stability over time of variables measuring heart rate variability in normal subjects. Am J Cardiol 68(6):626–630 · DOI
  28. Van Hoogenhuyze D, Weinstein N, Martin GJ et al (1991) Reproducibility and relation to mean heart rate of heart rate variability in normal subjects and in patients with congestive heart failure secondary to coronary artery disease. Am J Cardiol 68(17):1668–1676 · DOI
  29. Abildstrom SZ, Jensen BT, Agner E et al (2003) Heart rate versus heart rate variability in risk prediction after myocardial infarction. J Cardiovasc Electrophysiol 14(2):168–173 · DOI
  30. Kautzner J, Hnatkova K, Staunton A, Camm AJ, Malik M (1995) Day-to-day reproducibility of time-domain measures of heart rate variability in survivors of acute myocardial infarction. Am J Cardiol 76(4):309–312 · DOI
  31. Yi G, Gallagher MM, Yap YG et al (2000) Consistency of multicenter measurements of heart rate variability in survivors of acute myocardial infarction. Pacing Clin Electrophysiol 23(2):157–164 · DOI
  32. Stein PK, Rich MW, Rottman JN, Kleiger RE (1995) Stability of index of heart rate variability in patients with congestive heart failure. Am Heart J 129(5):975–981 · DOI

Cited by

Sorted by citations

See all 7

Metadata

Authors
Bjelakovic, B., Ilic, D., Lukic, S., Vukomanovic, V., Zarko, C., Stankovic, Z., & Marko, J.
Affiliations
  • University of Nis (RS)
  • University of Belgrade (RS)
Corresponding author
Bjelakovic, Bojko
ORCID
Venue
Clinical Autonomic Research
Publisher
Springer Science and Business Media LLC
Published
2017-06-30
Volume
27
Issue
4
Pages
273-278
ISSN
  • 0959-9851 (ISSN-L)
  • 1619-1560
DOI
10.1007/s10286-017-0445-3
OpenAlex
W2734039738
Cited by
7
References
1
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2020: 2 · 2019: 1 · 2018: 1
FWCI
0.85
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (unspecified)
Locations
  • Clinical Autonomic Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › ECG Monitoring and Analysis
Keywords
heart rate variability, reproducibility, 24-hour Holter monitoring, time-domain HRV, heart rate correction, cardiac autonomic tone, children, healthy children
MeSH terms
Adolescent, Aging, Autonomic Nervous System, Child, Child, Preschool, Electrocardiography, Female, Heart Rate, Humans, Infant, Male, Reference Values, Reproducibility of Results, Electrocardiography, Ambulatory, Healthy Volunteers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Reproducibility of 24-h heart rate variability in children. https://app.cochat.ai/papers/10.1007/s10286-017-0445-3
The paper
Bjelakovic, B., Ilic, D., Lukic, S., Vukomanovic, V., Zarko, C., Stankovic, Z., & Marko, J. (2017). Reproducibility of 24-h heart rate variability in children. Clinical Autonomic Research. https://doi.org/10.1007/s10286-017-0445-3