REM sleep behavior disorder, autonomic dysfunction and synuclein-related neurodegeneration: where do we stand?
Abstract
Introduction From newfound parasomnia to a marker of future synucleinopathy, since its first description in 1986, REM sleep behavior disorder (RBD) has been systematically tackled from virtually many viewpoints in basic, translational, and clinical studies. The time delay between RBD and synucleinopathy onset offers an exceptional window for observation and design of neuroprotective trials. In the last few years, research has focused on characterizing possible differences within RBD patients in order to draw potential profiles more or less susceptible to further neurodegeneration. Attention has been drawn towards autonomic dysfunction in RBD as one of such variables. Overview In this review, REM sleep physiology and relevant brain anatomy is briefly mentioned and integrated with neuroanatomical and physiological concepts regarding the central autonomic network. A detailed summary of works showing the presence of autonomic dysfunction in RBD is provided, and clinical and electrophysiological features of RBD in synucleinopathies are discussed. A short overview of RBD in other neurodegenerative diseases is also provided.
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“Interestingly, individuals with RBD often show prominent autonomic dysfunction (Chiaro et al., 2017; Ferini-Strambi et al., 2014; Frauscher et al., 2012; Miglis et al., 2017).”
- Authors
- Chiaro, G., Calandra-Buonaura, G., Cecere, A., Mignani, F., Sambati, L., Loddo, G., Cortelli, P., & Provini, F.
- Affiliations
- Ospedale Bellaria (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Corresponding author
- Provini, Federica
- ORCID
- Venue
- Clinical Autonomic Research
- Published
- 2017-09-04
- Volume
- 28
- Issue
- 6
- Pages
- 519-533
- ISSN
- 0959-9851 (ISSN-L)
- 1619-1560
- OpenAlex
- W2751908082
- Cited by
- 42
- References
- 8
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 6 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 6 · 2018: 9
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Autonomic Research (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- REM sleep behavior disorder, autonomic dysfunction, synucleinopathies, alpha-synuclein, neurodegeneration, central autonomic network, parasomnias, neurodegenerative diseases
- MeSH terms
- Autonomic Nervous System Diseases, Humans, Neurodegenerative Diseases, REM Sleep Behavior Disorder, Synucleins
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