The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Infliximab in Ulcerative Colitis is Associated with an Increased Risk of Postoperative Complications After Restorative Proctocolectomy
Abstract
PURPOSE: Little data exist regarding infliximab use in surgical decision making and postoperative complications in ulcerative colitis. Our goals were to determine the rate of postoperative complications in infliximab-treated ulcerative colitis patients undergoing restorative proctocolectomy and to determine whether three-stage procedures are more often necessary. METHODS: We studied a group of infliximab-treated patients and matched control subjects who underwent two-stage restorative proctocolectomy between 2000 and 2006. Postoperative complications were compared. In addition, the rate of three-stage procedures was compared between all infliximab- and noninfliximab-treated patients. RESULTS: A total of 523 restorative proctocolectomies were performed. In the infliximab group, there were 46 two-stage and 39 three-stage procedures. Covariate-adjusted odds of early complication for the infliximab group was 3.54 times that of controls (P = 0.004; 95 percent confidence interval (CI), 1.51-8.31). The odds of sepsis were 13.8 times greater (P = 0.011; 95 percent CI, 1.82-105) and the odds of late complication were 2.19 times greater (P = 0.08; 95 percent CI, 0.91-5.28) for infliximab. The odds of requirement for three-stage procedures was 2.07 times greater in the infliximab group (P = 0.011; 95 percent CI, 1.18-3.63). CONCLUSIONS: Infliximab increases the risk of postoperative complications after restorative proctocolectomy and has altered the surgical approach to ulcerative colitis. Potential benefits of infliximab should be balanced against these risks.
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Cites
Infliximab for Induction and Maintenance Therapy for Ulcerative Colitis
Rutgeerts, P., Sandborn, W. J., Feagan, B. G., Reinisch, W., Olson, A., Johanns, J., Travers, S., Rachmilewitz, D., Hanauer, S. B., Lichtenstein, G. R., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050516 · Cited by 3,902
Proctocolectomy without ileostomy for ulcerative colitis.
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IIeal Pouch-Anal Anastomoses Complications and Function in 1005 Patients
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Laboratory markers in IBD: useful, magic, or unnecessary toys?
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Serious Infections and Mortality in Association With Therapies for Crohn’s Disease: TREAT Registry
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Colombel, J.-F., Loftus, E. V., Tremaine, W. J., Egan, L. J., Harmsen, W. S., Schleck, C. D., Zinsmeister, A. R., & Sandborn, W. J. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.10.047 · Cited by 899
Long-Term Functional Outcome and Quality of Life After Stapled Restorative Proctocolectomy
Fazio, V. W., O’Riordain, M. G., Lavery, I. C., Church, J. M., Lau, P., Strong, S. A., & Hull, T. (1999) · Annals of Surgery · doi:10.1097/00000658-199910000-00013 · Cited by 453
Infliximab in the Treatment of Severe, Steroid-Refractory Ulcerative Colitis: A Pilot Study
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Cited by
Magro, F., Gionchetti, P., Eliakim, R., Ardizzone, S., Armuzzi, A., Barreiro-de Acosta, M., Burisch, J., Gecse, K. B., Hart, A. L., Hindryckx, P., et al. (2017) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjx008 · Cited by 1,910
Kobayashi, T., Siegmund, B., Le Berre, C., Wei, S. C., Ferrante, M., Shen, B., Bernstein, C. N., Danese, S., Peyrin-Biroulet, L., & Hibi, T. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0205-x · Cited by 1,649
Self-citationDignass, A., Lindsay, J. O., Sturm, A., Windsor, A., Colombel, J.-F., Allez, M., D'Haens, G., D'Hoore, A., Mantzaris, G., Novacek, G., et al. (2012) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2012.09.002 · Cited by 1,548
European evidence based consensus on surgery for ulcerative colitis
Øresland, T., Bemelman, W. A., Sampietro, G. M., Spinelli, A., Windsor, A., Ferrante, M., Marteau, P., Zmora, O., Kotze, P. G., Espin-Basany, E., et al. (2015) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2014.08.012 · Cited by 353
37 Drugs that act on the immune system: cytokines and monoclonal antibodies
Vial, T., Descotes, J., Braun, F., & Behrend, M. (2007) · Side effects of drugs annual · doi:10.1016/s0378-6080(06)29037-8 · Cited by 3
Metadata
- Authors
- Mor, I. J., Vogel, J. D., da Luz Moreira, A., Shen, B., Hammel, J., & Remzi, F. H.
- Venue
- Diseases of the Colon & Rectum
- Published
- 2008-08
- Volume
- 51
- Issue
- 8
- Pages
- 1202-1210
- ISSN
- 0012-3706 (ISSN-L)
- OpenAlex
- W1996835391
- Cited by
- 297
- References
- 22
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mor, I. J., Vogel, J. D., da Luz Moreira, A., Shen, B., Hammel, J., & Remzi, F. H. (2008). Infliximab in Ulcerative Colitis is Associated with an Increased Risk of Postoperative Complications After Restorative Proctocolectomy. Diseases of the Colon & Rectum. https://doi.org/10.1007/s10350-008-9364-7
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