Cited by 296Medication Adherence and ComplianceHIV/AIDS Research and InterventionsPharmacy and Medical Practices

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Validation of a New Three-Item Self-Report Measure for Medication Adherence

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Wilson, Ira B., Lee, Yoojin, Michaud, Joanne, Fowler, Floyd J., Rogers, William H.·2016·AIDS and Behavior

DOI 10.1007/s10461-016-1406-xPMC PMC5071118

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Abstract

Few self-report measures of medication adherence have been rigorously developed and validated against electronic drug monitoring (EDM). Assess the validity of the 3-item self-report scale by comparing it with a contemporaneous EDM measure. We conducted an observational study in which adherence assessments were done monthly for up to 4 months for 81 patients with HIV who were taking antiretroviral medications. We report results for both HIV antiretroviral medications, and also for other, non-HIV-related medications. Raw and calibrated self-report adherence measures, electronic drug monitoring adherence measures, and sociodemographic variables. The mean age of patients was 46 years, 37 % were female, 49 % had some education beyond high school, 22 % were Black, and 22 % were Hispanic. Cronbach's alphas for the 3-item scale for HIV and non-HIV medications were 0.83 and 0.87, respectively. The mean differences (raw/uncalibrated self-report scale minus EDM) for HIV and non-HIV medications were 7.5 and 5.2 points on a 100-point scale (p < 0.05 for both). Pearson correlation coefficients between the calibrated 3-item scale and the EDM for HIV and non-HIV medications were 0.47 and 0.59, respectively. The c-statistics for the ROC curves for the calibrated scale, using cut-offs of 0.8 and 0.9 for the EDM gold standard measure to define non-adherence, were between 0.74 and 0.76 for HIV and non-HIV medications. This 3-item adherence self-report scale showed good psychometric characteristics and good construct validity when compared with an EDM standard, for both HIV and non-HIV medications. In clinical care it can be a useful first-stage screener for non-adherence. In clinical research and quality improvement settings it can be a useful tool when more complex and expensive methods such as EDM or pharmacy claims are impractical or unavailable.

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Additional file 3 of Development of a multicomponent implementation strategy to reduce upper gastrointestinal bleeding risk in patients using warfarin and antiplatelet therapy, and protocol for a pragmatic multilevel randomized factorial pilot implementation trial
Kurlander, J. E., Helminski, D., Lanham, M. S. M., Henstock, J. L., Kidwell, K., Krein, S. L., Saini, S. D., Richardson, C. R., Vries, R. G. D., Resnicow, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19090827
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Additional file 6 of Development of a multicomponent implementation strategy to reduce upper gastrointestinal bleeding risk in patients using warfarin and antiplatelet therapy, and protocol for a pragmatic multilevel randomized factorial pilot implementation trial
Kurlander, J. E., Helminski, D., Lanham, M. S. M., Henstock, J. L., Kidwell, K., Krein, S. L., Saini, S. D., Richardson, C. R., Vries, R. G. D., Resnicow, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19090836
Additional file 4 of Development of a multicomponent implementation strategy to reduce upper gastrointestinal bleeding risk in patients using warfarin and antiplatelet therapy, and protocol for a pragmatic multilevel randomized factorial pilot implementation trial
Kurlander, J. E., Helminski, D., Lanham, M. S. M., Henstock, J. L., Kidwell, K., Krein, S. L., Saini, S. D., Richardson, C. R., Vries, R. G. D., Resnicow, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19090830
Additional file 10 of Development of a multicomponent implementation strategy to reduce upper gastrointestinal bleeding risk in patients using warfarin and antiplatelet therapy, and protocol for a pragmatic multilevel randomized factorial pilot implementation trial
Kurlander, J. E., Helminski, D., Lanham, M. S. M., Henstock, J. L., Kidwell, K., Krein, S. L., Saini, S. D., Richardson, C. R., Vries, R. G. D., Resnicow, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19090812
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Additional file 7 of Development of a multicomponent implementation strategy to reduce upper gastrointestinal bleeding risk in patients using warfarin and antiplatelet therapy, and protocol for a pragmatic multilevel randomized factorial pilot implementation trial
Kurlander, J. E., Helminski, D., Lanham, M. S. M., Henstock, J. L., Kidwell, K., Krein, S. L., Saini, S. D., Richardson, C. R., Vries, R. G. D., Resnicow, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19090839
Additional file 9 of Development of a multicomponent implementation strategy to reduce upper gastrointestinal bleeding risk in patients using warfarin and antiplatelet therapy, and protocol for a pragmatic multilevel randomized factorial pilot implementation trial
Kurlander, J. E., Helminski, D., Lanham, M. S. M., Henstock, J. L., Kidwell, K., Krein, S. L., Saini, S. D., Richardson, C. R., Vries, R. G. D., Resnicow, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19090845
Additional file 11 of Development of a multicomponent implementation strategy to reduce upper gastrointestinal bleeding risk in patients using warfarin and antiplatelet therapy, and protocol for a pragmatic multilevel randomized factorial pilot implementation trial
Kurlander, J. E., Helminski, D., Lanham, M. S. M., Henstock, J. L., Kidwell, K., Krein, S. L., Saini, S. D., Richardson, C. R., Vries, R. G. D., Resnicow, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19090818
Additional file 8 of Development of a multicomponent implementation strategy to reduce upper gastrointestinal bleeding risk in patients using warfarin and antiplatelet therapy, and protocol for a pragmatic multilevel randomized factorial pilot implementation trial
Kurlander, J. E., Helminski, D., Lanham, M. S. M., Henstock, J. L., Kidwell, K., Krein, S. L., Saini, S. D., Richardson, C. R., Vries, R. G. D., Resnicow, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19090842
Additional file 2 of Development of a multicomponent implementation strategy to reduce upper gastrointestinal bleeding risk in patients using warfarin and antiplatelet therapy, and protocol for a pragmatic multilevel randomized factorial pilot implementation trial
Kurlander, J. E., Helminski, D., Lanham, M. S. M., Henstock, J. L., Kidwell, K., Krein, S. L., Saini, S. D., Richardson, C. R., Vries, R. G. D., Resnicow, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19090824
Additional file 5 of Development of a multicomponent implementation strategy to reduce upper gastrointestinal bleeding risk in patients using warfarin and antiplatelet therapy, and protocol for a pragmatic multilevel randomized factorial pilot implementation trial
Kurlander, J. E., Helminski, D., Lanham, M. S. M., Henstock, J. L., Kidwell, K., Krein, S. L., Saini, S. D., Richardson, C. R., Vries, R. G. D., Resnicow, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19090833
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Additional file 1 of Development of a multicomponent implementation strategy to reduce upper gastrointestinal bleeding risk in patients using warfarin and antiplatelet therapy, and protocol for a pragmatic multilevel randomized factorial pilot implementation trial
Kurlander, J. E., Helminski, D., Lanham, M. S. M., Henstock, J. L., Kidwell, K., Krein, S. L., Saini, S. D., Richardson, C. R., Vries, R. G. D., Resnicow, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19090821
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Authors: Wilson, I. B., Lee, Y., Michaud, J., Fowler, F. J., & Rogers, W. H.
Affiliations: Brown University (US)
University of Massachusetts Boston (US)
Tufts Medical Center (US)
Corresponding author: Wilson, Ira B.
ORCID: Wilson, Ira B.
Lee, Yoojin
Fowler, Floyd J.
Venue: AIDS and Behavior
Publisher: Springer Science and Business Media LLC
Published: 2016-04-20
Volume: 20
Issue: 11
Pages: 2700-2708
ISSN: 1090-7165 (ISSN-L)
1573-3254
DOI: 10.1007/s10461-016-1406-x
PMC: PMC5071118
OpenAlex: W2340311148
Cited by: 296
References: 34
Citations by year: 2026: 19 · 2025: 42 · 2024: 43 · 2023: 29 · 2022: 52 · 2021: 33 · 2020: 33 · 2019: 24 · 2018: 10 · 2017: 6 · 2016: 3
FWCI: 17.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: AIDS and Behavior (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (RO1 MH 092238, 2K24MH092242)
Topics: Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
Keywords: medication adherence, HIV antiretroviral therapy, psychometric validation, adherence screening
MeSH terms: Adult, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Psychometrics, Surveys and Questionnaires, HIV Infections, Drug Monitoring, Anti-HIV Agents, Medication Adherence, Electronic Health Records, Self Report

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Validation of a New Three-Item Self-Report Measure for Medication Adherence

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