Agentic AI systems in the age of generative models: architectures, cloud scalability, and real-world applications
Open accessAbstract
This research proposes a holistic agentic Artificial Intelligence framework that seeks to solve the palpable requirement of autonomy, versatility, and world-scale generative Artificial Intelligence systems. When framing the concept of an agentic Artificial Intelligence as a paradigm shift where Large Language Models are relatively reactive, tool-augmented to a proactive, modular agent that pursues goals in the long term, the research discusses how large language models are becoming an architectural mandate. The proposed research uses a skillful literature synthesis and develops a concept and technical framework that integrates perception, memory, planning, execution, and communication modules. In contrast to current frameworks like AutoGPT and ReAct, where the deep memory, explainability, and certain control of scalability are often lacking, the proposed framework offers a solution with persistent memory layers, semantic routing, and modular orchestration pipelines when it comes to cloud-native deployments. Experimental verification offers a greater degree of autonomy, coordination, and resilience in a diverse range of activities such as enterprise automation and robotics. It is also an edge deployment with the help of lightweight microservices framework. In practice, this method supports scaled, comprehensible agents adapted to long-loop thinking and human-in-the-loop management and adaptive value chain serving. The novelty of the work is attributed to its reusable architecture, as it is not only capable of modifying agentic behavior alone, but it can also connect the theoretical principles and industry feasibility. Future efforts will be with the integration of ethical governance, uniform benchmarking, and multimodal memory remodeling in next generation of real-world autonomous systems.
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Recent advances in biomedical artificial intelligence increasingly highlight the importance of systems capable of coordinating reasoning and tool use in complex, multistage workflows.
“Recent advances in biomedical artificial intelligence increasingly highlight the importance of systems capable of coordinating reasoning and tool use in complex, multistage workflows [17, 26, 38, 41].”
From The next paradigm in bioinformatics: a review of multi-agent systems and foundational models for end-to-end scientific discovery (2026) · cites this paper as [41]
The four PARM components allow a structured comparison of heterogeneous agents, whose maturity varies substantially depending on study design, validation setting, and external reproducibility.
“The four components allow for a structured comparison of heterogeneous agents, whose maturity varies substantially depending on study design, validation setting, and external reproducibility [26, 38, 41]:”
From The next paradigm in bioinformatics: a review of multi-agent systems and foundational models for end-to-end scientific discovery (2026) · cites this paper as [41]
Most current biomedical studies of agentic systems fall within conceptual/architectural proposals or controlled evaluations of prototypes, and only a limited subset provides robust external validation or analysis of generalizability across institutions.
“Most current biomedical studies fall within the first two levels, and only a limited subset provides robust external validation or analysis of generalizability across institutions [26, 38, 41].”
From The next paradigm in bioinformatics: a review of multi-agent systems and foundational models for end-to-end scientific discovery (2026) · cites this paper as [41]
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References 21 · Cited by 32
- Authors
- Alva, L. R., & Pandey, B.
- Affiliations
- G.L. Bajaj Institute of Technology and Management Greater Noida (IN)
- Corresponding author
- Pandey, Bishwajeet
- Venue
- Artificial Intelligence Review
- Published
- 2026-01-12
- Volume
- 59
- Issue
- 3
- ISSN
- 0269-2821 (ISSN-L)
- 1573-7462
- OpenAlex
- W7122857583
- Cited by
- 32
- References
- 21
- Citations by year
- 2026: 32
- FWCI
- 109.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Artificial Intelligence Review (publishedVersion, cc-by-nc-nd)
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › Artificial Intelligence Applications
- Physical Sciences › Computer Science › Artificial Intelligence › AI-based Problem Solving and Planning
- Physical Sciences › Computer Science › Artificial Intelligence › Psychiatry, Mental Health, Neuroscience
- Keywords
- agentic AI, large language models, autonomous agents, agent architecture, persistent memory, semantic routing, cloud scalability, cloud-native deployment, edge deployment, microservices, enterprise automation, robotics, human-in-the-loop, long-term planning, explainability, React
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