Plaques, Tangles, and Memory Loss in Mouse Models of Neurodegeneration
Abstract
Within the past decade, our understanding of the pathogenic mechanisms in Alzheimer's disease (AD) has dramatically advanced because of the development of transgenic mouse models that recapitulate the key pathological and behavioral phenotypes of the disease. These mouse models have allowed investigators to test detailed questions about how pathology develops and to evaluate potential therapeutic approaches that could slow down the development of this disease. In this review, we discuss the status of transgenic mouse models and review the complex relationship between pathology and behavior in the development of neuropathological syndromes in AD.
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In vivo animal models can recapitulate Alzheimer's disease features by transgenic expression of human familial AD genes, which lead to spontaneous formation of Aβ plaques and neurofibrillary tangles.
“The in vivo animal models can recapitulate AD disease features by the transgenic expression of human familial AD genes which lead to spontaneously formation of Aβ plaques and neurofibrillary tangles.13, 14”
From Acoustofluidic assembly of 3D neurospheroids to model Alzheimer's disease (2020) · cites this paper as [14]
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References 232 · Cited by 146
- Authors
- Eriksen, J. L., & Janus, C. G.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Janus, Christopher G.
- Venue
- Behavior Genetics
- Published
- 2006-10-28
- Volume
- 37
- Issue
- 1
- Pages
- 79-100
- ISSN
- 0001-8244 (ISSN-L)
- 1573-3297
- OpenAlex
- W2090023755
- Cited by
- 146
- References
- 232
- Citations by year
- 2025: 3 · 2024: 16 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 9 · 2012: 12
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Behavior Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, transgenic mouse model, amyloid plaques, neurofibrillary tangles, memory loss, pathogenesis, treatment options
- MeSH terms
- Alzheimer Disease, Animals, Cognition Disorders, Disease Models, Animal, Humans, Memory Disorders, Mice, Transgenic, Amyloid beta-Peptides, Neurofibrillary Tangles, tau Proteins, Mice, Plaque, Amyloid
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