Suppression of the aging-associated decline in physical performance by a combination of resveratrol intake and habitual exercise in senescence-accelerated mice
Abstract
The decline in physical performance with increasing age is a crucial problem in our aging society. We examined the effects of resveratrol, a natural polyphenolic compound present in grapes, in combination with habitual exercise on the aging-associated decline in physical performance in senescence-accelerated prone mice (SAMP1). The endurance capacity of SAMP1 mice undergoing an exercise regimen (SAMP1-Ex) decreased over 12 weeks whereas that of SAMP1 mice fed 0.2% (w/w) resveratrol along with exercise (SAMP1-ExRes) remained significantly higher. In the SAMP1-ExRes group, there was a significant increase in oxygen consumption and skeletal muscle mRNA levels of mitochondrial function-related enzymes. These results suggest that the intake of resveratrol, together with habitual exercise, is beneficial for suppressing the aging-related decline in physical performance and that these effects are attributable, at least in part, to improved mitochondrial function in skeletal muscle.
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Resveratrol promotes fat oxidation in mice.
“Resveratrol has been shown to promote fat oxidation and enhance endurance performance in mice [174].”
From New strategies in sport nutrition to increase exercise performance (2016) · cites this paper as [174]
Resveratrol enhances endurance performance in mice.
“Resveratrol has been shown to promote fat oxidation and enhance endurance performance in mice [174].”
From New strategies in sport nutrition to increase exercise performance (2016) · cites this paper as [174]
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References 40 · Cited by 125
- Authors
- Murase, T., Haramizu, S., Ota, N., & Hase, T.
- Affiliations
- Kao Corporation (Japan) (JP)
- Corresponding author
- Murase, Takatoshi
- Venue
- Biogerontology
- Published
- 2008-10-01
- Volume
- 10
- Issue
- 4
- Pages
- 423-434
- ISSN
- 1389-5729 (ISSN-L)
- 1573-6768
- OpenAlex
- W1990567121
- Cited by
- 125
- References
- 40
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 13 · 2018: 4 · 2017: 6 · 2016: 12 · 2015: 11 · 2014: 10 · 2013: 11 · 2012: 9
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biogerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- resveratrol, physical performance, aging, senescence-accelerated mice, SAMP1, physical activity, endurance capacity, mitochondrial function, skeletal muscle, oxygen consumption, polyphenols, mitochondrial enzymes
- MeSH terms
- Resveratrol, Age Factors, Aging, Animals, Energy Metabolism, Physical Exertion, Male, Mice, Mutant Strains, Mitochondria, Muscle, Oxygen Consumption, Physical Endurance, RNA, Messenger, Running, Stilbenes, Time Factors, Lipid Peroxidation, Biomarkers, Gene Expression Regulation, Enzymologic, Muscle, Skeletal, Mitochondrial Proteins, Mice, Muscle Strength
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