A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta

Bielak-Zmijewska, Anna; Wnuk, Maciej; Przybylska, Dorota; Grabowska, Wioleta; Lewinska, Anna; Alster, Olga; Korwek, Zbigniew; Cmoch, Anna; Myszka, Aleksander; Pikula, Slawomir; Mosieniak, Grazyna; Sikora, Ewa

doi:10.1007/s10522-013-9477-9

A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta

Senescence of vascular smooth muscle cells (VSMCs) contributes to aging as well as age-related diseases of the cardiovascular system. Senescent VSMCs have been shown to be present in atherosclerotic plaques. Both replicative (RS) and stress-induced premature senescence (SIPS) accompany cardiovasc…