Relationship between mRNA stability and length: an old question with a new twist
Abstract
The half-life of individual mRNA plays a central role in controlling the level of gene expression. However, the determinants of mRNA stability have not yet been well defined. Most previous studies suggest that mRNA length does not affect its stability. Here, we show significant negative correlations between mRNA length and stability in human and Escherichia coli, but not in Saccharomyces cerevisiae or Bacillus subtilis. This finding suggests the possibility that endonucleolytic attacks by RNA endonuclease and/or mechanical damage may strongly influence mRNA stability in both prokaryotes and eukaryotes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
mRNA length has been shown to negatively correlate with stability.
“In particular, mRNA length has been shown to negatively correlate with stability, which would explain our observations (Feng and Niu, 2007).”
From Evaluating Efficiencies of Dual AAV Approaches for Retinal Targeting (2017) · cites this paper as Feng and Niu, 2007
Cited by
Sorted by citations
Vogel, C., de Sousa Abreu, R., Ko, D., Le, S., Shapiro, B. A., Burns, S. C., Sandhu, D., Boutz, D. R., Marcotte, E. M., & Penalva, L. O. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.59 · Cited by 608 · see citing works
Evaluating Efficiencies of Dual AAV Approaches for Retinal Targeting
Carvalho, L. S., Turunen, H. T., Wassmer, S. J., Luna-Velez, M. V., Xiao, R., Bennett, J., & Vandenberghe, L. H. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00503 · Cited by 86 · see citing works
- Authors
- Feng, L., & Niu, D.-K.
- Affiliations
- Beijing Normal University (CN)
- Corresponding author
- Niu, Deng-Ke
- ORCID
- Niu, Deng-Ke
- Venue
- Biochemical Genetics
- Published
- 2007-01-13
- Volume
- 45
- Issue
- 1-2
- Pages
- 131-137
- ISSN
- 0006-2928 (ISSN-L)
- 1573-4927
- OpenAlex
- W2084585383
- Cited by
- 58
- References
- 0
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biochemical Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Lunds Universitet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- mRNA stability, mRNA half-life, mRNA length, gene expression regulation, RNA endonuclease, eukaryotic mRNA
- MeSH terms
- Bacillus subtilis, Base Sequence, Escherichia coli, Half-Life, Humans, RNA, Messenger, Saccharomyces cerevisiae, Open Reading Frames, RNA Stability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
