Effects of aluminum trichloride on the cartilage stimulatory growth factors in rats
Abstract
Aluminum (Al) is considered to be a potentially toxic metal and inhibits cartilage formation. Transforming growth factor β1 (TGF-β1) and bone morphogenetic protein 2 (BMP-2) are cartilage stimulatory growth factors, which play important roles in regulating the cartilage formation. To investigate the effects of aluminum trichloride (AlCl 3) on the regulation of cartilage formation. Eighty Wistar rats were orally exposed to 0 (control group), 0.4 g/L (low-dose group), 0.8 g/L (mid-dose group) and 1.6 g/L (high-dose group) AlCl 3 for 120 days, respectively. The rats body weight were decreased, the cartilage histological structure were disrupted, the cartilage and serum contents of Al and the serum level of C-telopeptide of type II collagen were all increased, the serum level of type II collagen (Col II) and alkaline phosphatase (ALP), and the mRNA expressions of TGF-β1, BMP-2, ALP and Col II were all decreased in the AlCl 3-treated groups compared with those in control group. These results indicate that AlCl 3 inhibits the cartilage formation through inhibition of the cartilage stimulatory growth factors expressions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Al inhibited activities of Na+K+-ATPase, Mg2+-ATPase and Ca2+-ATPase in erythrocytes, vascular endothelial cells, testes and ovaries of rats.
“There are reports showing that Al inhibited activities of Na+K+-ATPase, Mg2+-ATPase and Ca2+-ATPase in erythrocytes (Zhang et al., 2016), vascular endothelial cells (Vorbrodt et al., 1994), testes (Sun et al., 2018) and ovaries (Fu et al., 2014) of rats.”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Zhang et al., 2016
Cited by
Sorted by citations
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395 · see citing works
“The expression of cartilage stimulating growth factors, TGF-β1 and BMP-2, were inhibited by Al, thereby suppressing cartilage growth and disrupting cartilage structure (Zhang et al., 2017).”
Background
- Authors
- Zhang, F., Sun, X., Yu, H., Yang, X., Song, M., Han, Y., Li, Y., & Zhu, Y.
- Affiliations
- Northeast Agricultural University (CN)
- Jilin University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Corresponding author
- Li, Yanfei
- Zhu, Yanzhu
- Venue
- BioMetals
- Published
- 2016-11-24
- Volume
- 30
- Issue
- 1
- Pages
- 143-150
- ISSN
- 0966-0844 (ISSN-L)
- 1572-8773
- OpenAlex
- W2554045313
- Cited by
- 10
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 1
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BioMetals (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation Project (31372496, 31302147)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- aluminum chloride, aluminum toxicity, chondrogenesis, TGF-β1, BMP-2, type II collagen, alkaline phosphatase, oral exposure, gene expression, cartilage histology
- MeSH terms
- Aluminum Chloride, Aluminum, Animals, Body Weight, Cartilage, Chlorides, Gene Expression Regulation, Signal Transduction, Aluminum Compounds, Collagen Type II, Rats, Transforming Growth Factor beta1, Bone Morphogenetic Protein 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
