The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia.
Open accessAbstract
MicroRNAs (miRNAs) only recently have been recognized as promising molecules for both fundamental and clinical neuroscience. We provide a literature review of miRNA biomarker studies in three most prominent psychiatric disorders (depression, bipolar disorder and schizophrenia) with the particular focus on depression due to its social and healthcare importance. Our search resulted in 191 unique miRNAs across 35 human studies measuring miRNA levels in blood, serum or plasma. 30 miRNAs replicated in more than one study. Most miRNAs targeted neuroplasticity and neurodevelopment pathways. Various limitations do not allow us to make firm conclusions on clinical potential of studied miRNAs. Based on our results we discuss the rationale for future research investigations of exosomal mechanisms to overcome methodological caveats both in studying etiology and pathogenesis, and providing an objective back-up for clinical decisions.
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Changes in miRNA expression are connected to the pathogenesis of a variety of neurodegenerative diseases.
“Changes in miRNA expression are thought to be connected to the pathogenesis of a variety of neurodegenerative diseases [30].”
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References 204 · Cited by 75
- Authors
- Gruzdev, S. K., Yakovlev, A. A., Druzhkova, T. A., Guekht, A. B., & Gulyaeva, N. V.
- Affiliations
- Peoples' Friendship University of Russia (RU)
- Russian Academy of Sciences (RU)
- Moscow Research and Clinical Center for Neuropsychiatry (RU)
- Pirogov Russian National Research Medical University (RU)
- Corresponding author
- Gruzdev, S. K.
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2019-05-14
- Volume
- 39
- Issue
- 6
- Pages
- 729-750
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- PMC
- PMC11462851
- OpenAlex
- W2945478590
- Cited by
- 75
- References
- 204
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 7 · 2023: 16 · 2022: 10 · 2021: 13 · 2020: 12 · 2019: 2
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular and Molecular Neurobiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Russian Foundation for Fundamental Investigations (17-04-01079-a)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- microRNA, exosomes, depression, bipolar disorder, schizophrenia, microRNA biomarkers, blood-based biomarkers, neuroplasticity, brain development, mental illness
- MeSH terms
- Bipolar Disorder, Depression, Humans, Psychiatry, Schizophrenia, MicroRNAs, Exosomes
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