Restless Legs Syndrome in Patients with Irritable Bowel Syndrome: Response to Small Intestinal Bacterial Overgrowth Therapy
Abstract
Background Small intestinal bacterial overgrowth (SIBO) occurs in irritable bowel syndrome (IBS) and fibromyalgia. Since restless legs syndrome (RLS) occurs with fibromyalgia, a link between IBS, SIBO, and RLS was studied.Methods BS patients with abnormal lactulose breath tests received rifaximin 1,200 mg day(-1) for 10 days, followed by tegaserod 3 mg, long-term, and 1 month of zinc 220 mg day(-1) and once-daily probiotic (N = 11) or rifaximin monotherapy (N = 2). IBS symptom improvement was assessed after rifaximin. RLS symptoms, IBS symptoms, and overall IBS global improvement were assessed at last posttreatment visit: 8/10 patients were followed long-term (mean, 139 days; range, 54-450 days).Results Ten of 13 patients exhibited > or =80% improvement from baseline in RLS symptoms. Five maintained complete resolution of RLS symptoms. Global gastrointestinal symptom improvement was great (n = 6), moderate (n = 5), or mild (n = 2).Conclusion This study suggests that SIBO associated with IBS may be a factor in some RLS patients and SIBO therapy provides long-term RLS improvement.
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Small intestinal bacterial overgrowth is associated with fibromyalgia and restless legs syndrome.
“SIBO is associated with fibromyalgia40 and restless legs syndrome (RLS),41”
From The Gut Microbiome and the Brain (2014) · cites this paper as [41]
Treatment of SIBO produces clinically significant improvement in a small group of patients with restless legs syndrome.
“with treatment of SIBO producing clinically significant improvement in a small group of patients with RLS.41”
From The Gut Microbiome and the Brain (2014) · cites this paper as [41]
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References 43 · Cited by 56
- Authors
- Weinstock, L. B., Fern, S. E., & Duntley, S. P.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Weinstock, Leonard B.
- Venue
- Digestive Diseases and Sciences
- Published
- 2007-10-13
- Volume
- 53
- Issue
- 5
- Pages
- 1252-1256
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2100855685
- Cited by
- 56
- References
- 43
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 7
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Restless Legs Syndrome Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- restless legs syndrome, irritable bowel syndrome, small intestinal bacterial overgrowth, rifaximin, lactulose breath test, tegaserod, zinc supplementation, probiotics, gastrointestinal symptoms, long-term treatment outcomes
- MeSH terms
- Rifaximin, Adult, Breath Tests, Drug Therapy, Combination, Female, Gastrointestinal Agents, Humans, Indoles, Intestine, Small, Male, Middle Aged, Pilot Projects, Surveys and Questionnaires, Restless Legs Syndrome, Rifamycins, Treatment Outcome, Serotonin Receptor Agonists, Irritable Bowel Syndrome
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