Bone Marrow Stromal Cells Control the Growth of Hepatic Stellate Cells in vitro
Abstract
Liver cirrhosis is characterized by hepatic dysfunction, with extensive accumulation of fibrous tissue in the liver. Hepatic stellate cells (HSCs) are the major source of fibrillar matrix proteins and play an important role in the progress of liver cirrhosis. In our study, the growth of HSCs is inhibited by bone marrow stromal cells (BMSCs). The inhibition is irreversible and is followed by apoptosis. The effect of BMSCs on the apoptosis of HSCs is possibly via the JNK pathway activated by nerve growth factor (NGF) and hepatocyte growth factor (HGF) secreted by BMSCs. Meanwhile, the apoptosis effect is enhanced by transforming growth factor-beta blocking.
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MSCs induce HSC apoptosis by secreting HGF and NGF through activating the JNK pathway.
“Shi et al. found that MSCs induced HSC apoptosis by secreting HGF and NGF through activating the JNK pathway [182].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [182]
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Immune modulation by mesenchymal stem cells
Rasmusson, I. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.03.019 · Cited by 374 · see citing works
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Pan, X., Gao, T., & Wang, B. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01520-9 · Cited by 2 · see citing works
- Authors
- Shi, L., Li, G., Wang, J., Sun, B., Yang, L., Wang, G., Wang, D., Mu, L., Chen, H., Jin, L., Kostulas, N., & Li, H.
- Affiliations
- Harbin Medical University (CN)
- Corresponding author
- Li, Hulun
- Venue
- Digestive Diseases and Sciences
- Published
- 2008-03-20
- Volume
- 53
- Issue
- 11
- Pages
- 2969-2974
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2069020377
- Cited by
- 7
- References
- 1
- Citations by year
- 2025: 1 · 2015: 2 · 2014: 1 · 2012: 1
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- China Institute of Atomic Energy
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- mesenchymal stem cells, hepatic stellate cells, liver cirrhosis, HSC apoptosis, cell growth inhibition, JNK signaling, nerve growth factor, hepatocyte growth factor, TGF-beta, liver fibrosis
- MeSH terms
- Animals, Bone Marrow Cells, Cell Communication, Cells, Cultured, Signal Transduction, Transforming Growth Factor beta, Stromal Cells, Rats, Wistar, Apoptosis, Hepatocyte Growth Factor, Nerve Growth Factor, MAP Kinase Kinase 4, Cell Proliferation, Rats, Hepatic Stellate Cells
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