Partially Hydrolyzed Guar Gum Accelerates Colonic Transit Time and Improves Symptoms in Adults with Chronic Constipation
Abstract
Background and aim Partially hydrolyzed guar gum (PHGG) is a water-soluble, non-gelling dietary fiber with a wide range of uses in clinical nutrition. The aim of this prospective study was to investigate the effect of guar gum on colonic transit time (CTT) and symptoms of chronic constipation. Methods We enrolled patients fulfilling Rome III criteria for chronic constipation. CTT was measured before and at the end of treatment. After a 2-week run-in period, patients received 5 mg PHGG daily for 4 weeks. During study period, patients kept daily symptoms, stool and laxative usage diaries. They also recorded their symptom-related satisfaction weekly and treatment adverse events. Results Forty-nine patients received treatment; 39 (80 %) completed the study. Treatment significantly reduced colon transit time, from 57.28 ± 39.25 to 45.63 ± 37.27 h (p = 0.026), a reduction more prominent in slow transit patients (from 85.50 ± 27.75 to 63.65 ± 38.11 h, p = 0.016). Overall, the weekly number of complete spontaneous and spontaneous bowel movements increased significantly (p Conclusion Four-week PHGG use accelerates colon transit time in patients with chronic constipation, especially in those with slow transit, and improves many of their symptoms including frequency of bowel movements.
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PHGG accelerates colonic transit time in patients with chronic constipation.
“It accelerates colonic transit time in patients with chronic constipation (12).”
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Chan, T.-C., Yu, V. M. W., Luk, J. K. H., Chu, L. W., Yuen, J. K. Y., & Chan, F. H. W. (2022) · The Journal of nutrition, health and aging · doi:10.1007/s12603-022-1747-2 · Cited by 20 · see citing works
- Authors
- Polymeros, D., Beintaris, I., Gaglia, A., Karamanolis, G., Papanikolaou, I. S., Dimitriadis, G., & Triantafyllou, K.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Polymeros, Dimitrios
- Venue
- Digestive Diseases and Sciences
- Published
- 2014-04-08
- Volume
- 59
- Issue
- 9
- Pages
- 2207-2214
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2095432107
- Cited by
- 42
- References
- 4
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 2
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- partially hydrolyzed guar gum, chronic constipation, colonic transit time, slow transit constipation, dietary fiber, stool frequency, straining, stool consistency, laxative use, abdominal pain, Rome III criteria
- MeSH terms
- Adult, Aged, Chronic Disease, Colon, Constipation, Defecation, Dietary Fiber, Female, Galactans, Gastrointestinal Transit, Humans, Hydrolysis, Male, Mannans, Middle Aged, Prospective Studies, Severity of Illness Index, Patient Satisfaction, Dietary Supplements, Plant Gums, Laxatives
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