Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame
Open accessAbstract
With the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become a public health problem with increasing prevalence. The mechanism of disease progression remains obscure and effective therapy is lacking. Therefore, there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies. To accomplish this goal, experimental animal models that recapitulate the human disease are necessary, especially, since causative mechanistic studies of NAFLD are more difficult or unethical to perform in humans. A large number of studies regarding the pathophysiology and treatment of nonalcoholic steatohepatitis (NASH) have been undertaken in mice to model human NAFLD and NASH. This review discusses the known dietary, genetic, and inflammation-based animal models of NASH described in recent years, with a focus on the major advances made in this field.
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Rodent models of MASH comprise three broad categories: diet-based, genetic, and mixed.
“Rodent models of MASH have been extensively reviewed and comprise 3 broad categories: 1) diet-based; 2) genetic; or 3) mixed, which refers to combined diet, genetic, or chemical perturbations (118, 210-213).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [211]
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References 94 · Cited by 218
- Authors
- Ibrahim, S. H., Hirsova, P., Malhi, H., & Gores, G. J.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Gores, Gregory J.
- Venue
- Digestive Diseases and Sciences
- Published
- 2015-12-01
- Volume
- 61
- Issue
- 5
- Pages
- 1325-1336
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- PMC
- PMC4838538
- OpenAlex
- W2186318742
- Cited by
- 218
- References
- 94
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 24 · 2023: 16 · 2022: 27 · 2021: 29 · 2020: 31 · 2019: 17 · 2018: 27 · 2017: 21 · 2016: 10 · 2015: 1 · 2013: 1
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK41876, P30DK084567, DK97178)
- National Institutes of Health (KL2TR000136-09)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- nonalcoholic steatohepatitis, non-alcoholic fatty liver disease, animal models, mouse model, dietary models, genetic models, inflammation, obesity, pathogenesis
- MeSH terms
- Animals, Diet, Dietary Fats, Disease Models, Animal, Humans, Inflammation, Non-alcoholic Fatty Liver Disease
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