Analysis of Nausea in Clinical Studies of Lubiprostone for the Treatment of Constipation Disorders

Cryer, Byron; Drossman, Douglas A.; Chey, William D.; Webster, Lynn; Habibi, Sepideh; Wang, Martin

doi:10.1007/s10620-017-4680-1

Analysis of Nausea in Clinical Studies of Lubiprostone for the Treatment of Constipation Disorders

BackgroundLubiprostone is a ClC-2 chloride channel activator approved for the treatment of chronic idiopathic constipation (CIC) and opioid-induced constipation (OIC) in adults and irritable bowel syndrome with constipation (IBS-C) in women. Lubiprostone is generally well tolerated, with nausea b…