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Cited by 6Parasitic Diseases Research and TreatmentParasitic infections in humans and animalsHelminth infection and control

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Acute Anisakiasis: Pharmacological Evaluation of Various Drugs in an Animal Model

Gómez-Mateos, Magdalena, Arrebola, Francisco, Navarro, María Concepción, Romero, María Carmen, González, José María, Valero, Adela·2021·Digestive Diseases and Sciences
DOI 10.1007/s10620-020-06144-2
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Abstract

Background The accidental ingestion of the third larval stage of Anisakis can cause acute clinical symptoms, which are relieved via extraction of the larvae. Although this is a highly effective technique, it can only be practiced when the larvae are found in accessible areas of the gastrointestinal tract, and therefore instead the condition has often been treated using various different drugs. Aims This study evaluates the effectiveness of gastric acid secretion inhibitors (omeprazole and ranitidine), gastric mucosal protectants (sucralfate) and anthelmintics (mebendazole and flubendazole) in treating anisakiasis in Wistar rats. Methods Rats were infected with Anisakis-type I larvae and administered the drugs via a gastric probe. Data were recorded regarding the number of live and dead larvae, their location both within the animal and in its feces, and the presence of gastrointestinal lesions. Additionally, gastric pH was measured and histology performed. Results While rats in all experimental groups exhibited lesions; those treated with ranitidine and mebendazole showed significantly fewer lesions (50% and 35% of rats exhibited lesions, respectively). Histological examination of the gastric lesions revealed infection-induced changes, but no significant differences were observed between the treated and untreated rats. Conclusions Mebendazole was found to be most efficacious in preventing gastrointestinal lesions, followed by ranitidine, which was the most effective antacid of those studied. Both these drugs could thus be considered as part of the conservative management of anisakiasis.

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Metadata

Authors
Gómez-Mateos, M., Arrebola, F., Navarro, M. C., Romero, M. C., González, J. M., & Valero, A.
Affiliations
Universidad de Granada (ES)
ORCID
Venue
Digestive Diseases and Sciences
Publisher
Springer Science and Business Media LLC
Published
2020-02-27
Volume
66
Issue
1
Pages
105-113
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
DOI
10.1007/s10620-020-06144-2
OpenAlex
W3007258297
Cited by
6
References
0
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2021: 3
FWCI
0.13
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (BIO-243)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic infections in humans and animals
  • Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
Keywords
anisakiasis, Anisakis, mebendazole, ranitidine, omeprazole, sucralfate, flubendazole, anthelmintics, gastric acid secretion inhibitors, gastrointestinal lesions, larval migration, conservative treatment
MeSH terms
Acute Disease, Animals, Anthelmintics, Anti-Ulcer Agents, Antinematodal Agents, Disease Models, Animal, Drug Evaluation, Preclinical, Female, Fishes, Mebendazole, Omeprazole, Ranitidine, Sucralfate, Anisakiasis, Rats, Wistar, Gastrointestinal Tract, Rats

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Gómez-Mateos, M., Arrebola, F., Navarro, M. C., Romero, M. C., González, J. M., & Valero, A. (2021). Acute Anisakiasis: Pharmacological Evaluation of Various Drugs in an Animal Model. Digestive Diseases and Sciences. https://doi.org/10.1007/s10620-020-06144-2