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Cited by 12Plant Stress Responses and ToleranceSeed Germination and PhysiologyPlant Molecular Biology Research

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Abscisic acid (ABA) signaling: finding novel components off the beaten track

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Wong, Aloysius, Bi, Chuyun, Pasqualini, Stefania, Gehring, Chris·2022·Plant Growth Regulation
DOI 10.1007/s10725-022-00823-y

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Abstract

The sesquiterpene abscisic acid (ABA) is an ancient stress response molecule. In plants, many ABA-dependent processes operate via PYR/PYL/RCAR receptor complexes, but results from several studies have suggested that not all plant responses function through this mechanism. Since the ABA-dependent processes of animals and humans also operate in the absence of such receptors, we hypothesize that plant and animal proteomes harbour proteins with undiscovered ABA-binding sites. We propose that carefully curated amino acid search motifs deduced from the binding sites of experimentally confirmed ABA-binding proteins can identify many more candidates in plant and animal proteomes. Some of these candidates show structural folds that are compatible with ABA-binding. This approach identifies plant candidates including annotated ABA downstream signaling components SnRK2.2 and SnRK2.6, and proteins involved in protein folding and RNA polyadenylation. The identified ABA-binding candidates in the human proteome affect among other processes, immune responses and tumor progression. If these candidates are eventually validated experimentally, it will imply that the regulation and tuning of ABA-dependent processes is considerably more complex than hitherto suspected. It will also help to clarify the role of this conserved signaling molecule in mammals.

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Metadata

Authors
Wong, A., Bi, C., Pasqualini, S., & Gehring, C.
Affiliations
  • Wenzhou-Kean University (CN)
  • University of Perugia (IT)
Corresponding author
Gehring, Chris
ORCID
Venue
Plant Growth Regulation
Publisher
Springer Science and Business Media LLC
Published
2022-04-15
Volume
97
Issue
3
Pages
585-592
ISSN
  • 0167-6903 (ISSN-L)
  • 1573-5087
DOI
10.1007/s10725-022-00823-y
OpenAlex
W4226324762
Cited by
12
References
1
Citations by year
2026: 2 · 2025: 5 · 2024: 3 · 2022: 2
FWCI
1.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Plant Growth Regulation (publishedVersion, cc-by)
  • Research Square (acceptedVersion, cc-by)
Funders
  • National Natural Science Foundation of China (32100581)
  • International Collaborative Research Program of Wenzhou-Kean University (ICRP202202)
  • MUR–PRIN 2017 (2017N5LBZK_004)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Seed Germination and Physiology
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords
abscisic acid signaling, ABA receptors, PYR/PYL/RCAR receptors, SnRK2.6, protein folding, polyadenylation, immune response, tumor progression, plant stress response

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