T-Helper 1, T-Helper 2, and T-Regulatory Cytokines Gene Polymorphisms in Irritable Bowel Syndrome
Abstract
Inflammation and mucosal immune system activation have an important role in irritable bowel syndrome (IBS), whereas genetic factors can control some immunological mediators. In this study, a number of polymorphic genes coding for T-helper 1, T-helper 2, and T-regulatory cytokines were genotyped in 71 patients with IBS, and the results were compared with controls. IL-4 CC genotype at position -590, IL-4 TT genotype at position -33, and IL-10 GA genotype at position -1082 were significantly overrepresented in the patients with IBS in comparison with controls (P < 0.001). The frequencies of the following haplotypes in the patient group were significantly higher than in the control group: IL-2 (-330, +160) GT haplotype (P = 0.002), IL-4 (-1098, -590, -33) TCC haplotype (P < 0.001), and TCT haplotype (P < 0.001). While production of cytokines could be affected by genetic polymorphisms within coding and promoter regions of cytokine genes, IL-4 and IL-10 gene polymorphisms could affect individual susceptibility to IBS.
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IBS is associated with polymorphisms in genes involved in immune and inflammatory responses.
“Evidence supporting this hypothesis includes increased concentrations of inflammatory/immune cells in intestinal tissue from IBS patients, altered levels of pro- and anti-inflammatory cytokines in the GI tract and peripheral blood of patients with IBS (Table 1) (11, 13, 24, 36, 46, 50, 51, 62, 73, 75, 89, 90, 94, 98, 102, 118, 121–124, 168, 174, 185, 187), and IBS-associated polymorphisms in genes”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [16]
The prevalence of specific polymorphisms in the IL-10 gene in patients with IBS is not consistent across studies and may reflect the variety of ethnic groups in which these studies were conducted.
“However, the prevalence of specific polymorphisms in the IL-10 gene in patients with IBS are not consistent across studies and may reflect the variety of ethnic groups in which these studies were conducted (16).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [16]
Gene polymorphisms in TNF-α, IL-2, IL-4, IL-6, and IL-10 have been associated with IBS or PI-IBS.
“Gene polymorphisms (188) in TNF-α (15, 179), IL-2 (16), IL-4 (16), IL-6 (15), and IL-10 (16, 70) have been associated with IBS or PI-IBS (Table 2).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [16]
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References 35 · Cited by 46
- Authors
- Barkhordari, E., Rezaei, N., Mahmoudi, M., Larki, P., Ahmadi-Ashtiani, H. R., Ansaripour, B., Alighardashi, M., Bashashati, M., Amirzargar, A. A., & Ebrahimi-Daryani, N.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Children's Medical Center (IR)
- Zanjan University of Medical Sciences (IR)
- University of Calgary (CA)
- Imam Khomeini Hospital (IR)
- Corresponding author
- Ebrahimi-Daryani, Naser
- ORCID
- Venue
- Inflammation
- Published
- 2010-02-23
- Volume
- 33
- Issue
- 5
- Pages
- 281-286
- ISSN
- 0360-3997 (ISSN-L)
- 1573-2576
- OpenAlex
- W2035954008
- Cited by
- 46
- References
- 35
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 3 · 2013: 9 · 2012: 4
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Inflammation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, cytokine gene polymorphisms, regulatory T cells, IL-4, IL-10, interleukin-2, promoter polymorphism, haplotypes, genetic susceptibility, mucosal immunity
- MeSH terms
- Adult, Female, Gene Frequency, Haplotypes, Humans, Interleukin-2, Iran, Male, Middle Aged, Phenotype, Polymorphism, Genetic, Risk Factors, Interleukin-4, Chi-Square Distribution, Odds Ratio, Case-Control Studies, Cytokines, Interleukin-10, Th1 Cells, Th2 Cells, Risk Assessment, Genetic Predisposition to Disease, Irritable Bowel Syndrome, T-Lymphocytes, Regulatory
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