Localized delivery of curcumin from injectable gelatin/Thai silk fibroin microspheres for anti-inflammatory treatment of osteoarthritis in a rat model
Abstract
The previously developed gelatin/silk fibroin microspheres were loaded with curcumin and applied for anti-inflammatory treatment in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in a rat model. The MIA-induced OA rats received a single intra-articular injection with gelatin or gelatin/silk fibroin (30/70) microspheres encapsulating curcumin. The therapeutic effects of treatment groups [concentration of interleukin-6 (IL-6) in blood serum, radiographic and the histological grading on articular joint] were compared with those of normal saline treated OA and normal rats. The result showed that both microsphere groups reduced the level of IL-6 in serum after 1 week of treatment. The gelatin/silk fibroin (30/70) microspheres encapsulating curcumin delayed the cellular destruction in articular joint and synovial tissue after 8 weeks. The radiographic and histological gradings on articular cartilage lesion and synovial tissue change of rats treated with gelatin/silk fibroin (30/70) microspheres encapsulating curcumin were close to those of the normal rats. It was explained that the slow-degrading gelatin/silk fibroin (30/70) microspheres released curcumin for extended period and showed a prolonged anti-inflammatory effect, compared to the fast-degrading gelatin microspheres. This delivery system of curcumin was suggested to be applied for localized treatment of anti-inflammatory in OA with minimal invasion.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Animal studies have demonstrated that CURs administered via nano-scale drug carriers have potent anti-inflammatory and anti-arthritic activity for knee OA.
“Several animal studies have assessed the efficacy of CURs administered via nano-scale drug carriers for knee OA, demonstrating that CURs have potent anti-inflammatory and anti-arthritic activity, both with and without biological materials [19–23].”
Cites
Aggarwal, B. B., & Sung, B. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.11.002 · Cited by 1,140 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Feng, J., Li, Z., Tian, L., Mu, P., Hu, Y., Xiong, F., & Ma, X. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03740-9 · Cited by 33 · see citing works
- Authors
- Ratanavaraporn, J., Soontornvipart, K., Shuangshoti, S., Shuangshoti, S., & Damrongsakkul, S.
- Affiliations
- Chulalongkorn University (TH)
- Ministry of Public Health (TH)
- Corresponding author
- Damrongsakkul, Siriporn
- Venue
- Inflammopharmacology
- Published
- 2017-03-01
- Volume
- 25
- Issue
- 2
- Pages
- 211-221
- ISSN
- 0925-4692 (ISSN-L)
- 1568-5608
- OpenAlex
- W2593688149
- Cited by
- 48
- References
- 1
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 5 · 2023: 4 · 2022: 12 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Inflammopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Research Grant for New Scholar Ratchadaphiseksomphot Endowment Fund Chulalongkorn University (RGN_2558_019_02_21)
- Faculty of Engineering, Chulalongkorn University
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- curcumin, osteoarthritis, gelatin microspheres, silk fibroin, intra-articular injection, monosodium iodoacetate, interleukin-6, anti-inflammatory therapy, articular cartilage damage, synovium, sustained drug release, biodegradable microspheres
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
