Processing Speed and Neurodevelopment in Adolescent-Onset Psychosis: Cognitive Slowing Predicts Social Function
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Onset of psychosis may be associated with abnormal adolescent neurodevelopment. Here we examined the neurocognitive profile of first-episode, adolescent onset psychosis (AOP) as compared to typically developing adolescents, and asked whether neurocognitive performance varied differentially as a function of age in the cases compared with controls. A comprehensive neuropsychological battery was administered to 35 patients experiencing a first-episode of a DSM-IV psychotic disorder and to 31 matched controls. Clinicians also rated subjects' social and role functioning, both at the time of neuropsychological assessment and 1 year later. Although patients displayed a wide range of impairments relative to controls, their most pronounced deficits included verbal memory, sensorimotor dexterity and cognitive processing speed. Among these, only processing speed showed a significant group-by-age interaction, consistent with an aberrant developmental course among AOP patients. Processing speed also accounted for substantial variance in other areas of deficit, and predicted social functioning 1 year later. AOP patients fail to show normal age-related increases in processing speed, which in turn predicts poorer functional outcomes. This pattern is consistent with the view that adolescent brain developmental processes, such as myelination, may be disrupted in these patients.
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Bachman et al. (2012) reported that adolescent-onset psychosis patients do not show normal age-related increases in processing speed, which predicts poorer functional outcomes.
“It is noteworthy that Bachman et al. (2012) reported that adolescent-onset psychosis patients fail to show normal age-related increases in processing speed, which in turn predicts poorer functional outcomes.”
From Imaging Patterns of Brain Development and their Relationship to Cognition (2015) · cites this paper as Bachman et al. 2012
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References 51 · Cited by 33
Research works printed but not linked: 1
- Wechsler D 1997 Wechsler memory scale-third edition-(WMS-III) San Antonio, TX Harcourt Assessment
- Authors
- Bachman, P., Niendam, T. A., Jalbrzikowkski, M., Park, C. Y., Daley, M., Cannon, T. D., & Bearden, C. E.
- Affiliations
- University of California, Los Angeles (US)
- University of California, Davis (US)
- Corresponding author
- Bachman, Peter
- Venue
- Journal of Abnormal Child Psychology
- Published
- 2011-12-03
- Volume
- 40
- Issue
- 4
- Pages
- 645-654
- ISSN
- 0091-0627 (ISSN-L)
- 1573-2835
- PMC
- PMC4119229
- OpenAlex
- W2030648868
- Cited by
- 33
- References
- 51
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Research on Child and Adolescent Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K23MH087708, K23MH097040, P50MH066286)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- adolescent-onset psychosis, processing speed, cognitive slowing, brain development, first-episode psychosis, social functioning, verbal memory, age-related cognitive development, myelination, functional outcome prediction
- MeSH terms
- Adolescent, Analysis of Variance, Cognition Disorders, Female, Humans, Male, Memory, Mental Processes, Psychiatric Status Rating Scales, Psychomotor Disorders, Psychotic Disorders, Social Adjustment, Vocabulary, Case-Control Studies
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