Risperidone Improves Behavioral Symptoms in Children with Autism in a Randomized, Double-Blind, Placebo-Controlled Trial
Abstract
Subgroup analysis of children (5-12 years) with autism enrolled in an 8-week, double-blind, placebo-controlled trial of risperidone for pervasive developmental disorders. The primary efficacy measure was the Aberrant Behavior Checklist-Irritability (ABC-I) subscale. Data were available for 55 children given risperidone (n=27) or placebo (n=28); mean baseline ABC-I ( +/- SD) was 20.6 (8.1) and 21.6 (10.2). Risperidone [mean dose ( +/- SD): 1.37 mg/day (0.7)] resulted in significantly greater reduction from baseline to endpoint in ABC-I versus placebo [mean change ( +/- SD): -13.4 (1.5) vs. -7.2 (1.4), P<0.05; ES=-0.7]. The most common adverse effect with risperidone was somnolence (74% vs. 7% with placebo). Risperidone treatment was well tolerated and significantly improved behavioral problems associated with autism.
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Randomized controlled trials of risperidone in individuals with ASD found significant reductions in challenging behaviors, such as irritability and hyperactivity.
“randomized controlled trials of risperidone in individuals with ASD found significant reductions in challenging behaviors, such as irritability and hyperactivity [596-600]”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [599]
Cites
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- Authors
- Pandina, G. J., Bossie, C. A., Youssef, E., Zhu, Y., & Dunbar, F.
- Affiliations
- Janssen Canada (Canada) (CA)
- Corresponding author
- Pandina, Gahan J.
- ORCID
- Pandina, Gahan J.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2006-10-04
- Volume
- 37
- Issue
- 2
- Pages
- 367-373
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W2078913169
- Cited by
- 144
- References
- 3
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 10 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 12 · 2013: 7 · 2012: 11
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- risperidone, autism spectrum disorder, pervasive developmental disorders, irritability, Aberrant Behavior Checklist, behavioral symptoms, children, antipsychotic drugs, sleepiness, adverse effects
- MeSH terms
- Autistic Disorder, Child, Child, Preschool, Double-Blind Method, Female, Humans, Male, Psychomotor Disorders, Antipsychotic Agents, Treatment Outcome, Risperidone, Mood Disorders
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