Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity
Open accessAbstract
This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children's social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children's use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity.
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A secondary analysis of RUPP data linked methylphenidate to better joint attention initiation and response, improved self-regulation, and a more regulated affective state in 33 ASD children.
“Results indicated that methylphenidate use was associated with several positive social outcomes, including improved initiation for joint attention, improved response to bids for joint attention, better selfregulation, and more regulated affective state [50].”
From Treatment for Co-Occurring Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder (2012) · cites this paper as [50]
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References 46 · Cited by 144
- Authors
- Jahromi, L. B., Kasari, C. L., McCracken, J. T., Lee, L. S.-Y., Aman, M. G., McDougle, C. J., Scahill, L., Tierney, E., Eugene Arnold, L., Vitiello, B., Ritz, L., Witwer, A., Kustan, E., Ghuman, J., & Posey, D. J.
- Affiliations
- Arizona State University (US)
- University of California, Los Angeles (US)
- The Ohio State University (US)
- Indiana University Bloomington (US)
- Yale University (US)
- Kennedy Krieger Institute (US)
- National Institute of Mental Health (US)
- Corresponding author
- Jahromi, Laudan B.
- ORCID
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2008-08-28
- Volume
- 39
- Issue
- 3
- Pages
- 395-404
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC4374624
- OpenAlex
- W2131522463
- Cited by
- 144
- References
- 46
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 15 · 2019: 12 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 3 · 2014: 12 · 2013: 9 · 2012: 17
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Funders
- National Institutes of Health (n01mh070009-000, n01mh070001-008, n01mh080011-005)
- National Institute of Mental Health (N01-MH-80011, K23MH001883, T32MH018372, N01 MH-70001, U01MH070009, N01 MH 70009, MH 01805, N01MH70070, MH-68627, 5 T32 MH18372, K24MH001805, K23MH068627)
- National Institute on Drug Abuse (N01 MH080011)
- National Center for Research Resources (M01-RR 00750, M01 RR-00052, M01-RR-00034, M01RR006022, M01RR000750, M01RR000052, M01 RR-06022, M01RR000034)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- methylphenidate, pervasive developmental disorders, autism spectrum disorder, hyperactivity, social communication, self-regulation, joint attention, emotional behavior, children, stimulant medication, placebo-controlled crossover trial
- MeSH terms
- Adolescent, Central Nervous System Stimulants, Autistic Disorder, Child, Child Development Disorders, Pervasive, Child, Preschool, Dose-Response Relationship, Drug, Female, Humans, Male, Methylphenidate, Psychiatric Status Rating Scales, Psychomotor Agitation, Social Behavior, Social Control, Informal, Treatment Outcome, Cross-Over Studies, Asperger Syndrome
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