Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder
Open accessAbstract
Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive-compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples.
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In humans, SNPs within SLC1A1 have been associated with repetitive behaviors and anxiety in children with ASD, mental retardation, and obsessive compulsive disorder.
“In humans single nucleotide polymorphisms (SNPs) within this gene have been associated with repetitive behaviors and anxiety in children with ASD [67], mental retardation [68] and obsessive compulsive disorder [69], [70], [71], [72].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [67]
The Abstract reports an association between SLC1A1 rs301430 and anxiety severity in children with ASD, but says the repetitive-behavior analyses were not significant and calls the anxiety finding tentative. This verdict concerns the ASD clause attached to citation [67]; the other conditions have separate citations. Page numbers are not available in our copy. (LLM, conf=0.92)
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Cites
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Self-citationAlteration of Plasma Glutamate and Glutamine Levels in Children with High-Functioning Autism
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Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice
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“In humans single nucleotide polymorphisms (SNPs) within this gene have been associated with repetitive behaviors and anxiety in children with ASD [67], mental retardation [68] and obsessive compulsive disorder [69,70,71,72].”
BackgroundGlutamate mediated signaling in the pathophysiology of autism spectrum disorders
Choudhury, P. R., Lahiri, S., & Rajamma, U. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.06.023 · Cited by 121 · see citing works
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Anxiety in children with autism at school: a systematic review
Adams, D., Young, K., & Keen, D. (2019) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-019-00172-z · Cited by 76 · see citing works
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- Authors
- Gadow, K. D., Roohi, J., DeVincent, C. J., Kirsch, S., & Hatchwell, E.
- Affiliations
- Stony Brook University (US)
- Corresponding author
- Gadow, Kenneth D.
- ORCID
- Hatchwell, Eli
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2010-02-13
- Volume
- 40
- Issue
- 9
- Pages
- 1139-1145
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC4348063
- OpenAlex
- W2080699191
- Cited by
- 40
- References
- 8
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 5
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
- University of Galway Research Repository (submittedVersion, cc-by-nc)
- Research Repository UCD (University College Dublin) (cc-by-nc)
- Funders
- Deutsches Krebsforschungszentrum
- National Institutes of Health (M01RR10710)
- National Institute of General Medical Sciences (T32GM008444)
- National Center for Research Resources (#M01RR10710, M01RR010710)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, SLC1A1, glutamate transporters, single nucleotide polymorphisms, anxiety, repetitive behavior, obsessive-compulsive behavior, tics, genetic association, children, biomarkers
- MeSH terms
- Adolescent, Alleles, Anxiety, Child, Child Development Disorders, Pervasive, Child, Preschool, Female, Genotype, Humans, Male, Obsessive-Compulsive Disorder, Stereotypic Movement Disorder, Polymorphism, Single Nucleotide, Excitatory Amino Acid Transporter 3
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