Effects of intermittent intravenous saline infusions in patients with medication—refractory postural tachycardia syndrome
Abstract
Background The postural tachycardia syndrome (POTS) is a heterogeneous group of disorders that results in symptoms of orthostatic intolerance. Excess blood pooling has been observed to cause low effective circulating volume in the central vasculature. Consequently, acute volume loading with IV saline has emerged as a potential strategy for clinical intervention. We evaluated the impact of acute volume loading on both the signs and symptoms of patients suffering from POTS. Methods Fifty-seven subjects screened from our population of POTS patients and assenting to participation were administered the two surveys by telephone. Subjects completed each survey twice, before, and after initiating IV hydration therapy. The Orthostatic Hypotension Questionnaire (OHQ) was used to assess change in clinical symptomatology, while the short form 36 health survey (SF-36) was employed to assess the impact of IV saline infusion on quality of life. Results Fifty-seven patients were included in the analysis. The average number of medications trialed before referral for IV hydration was 3.6 ± 1.7 medications. Saline infusions occurred with mean frequency of 11.3 ± 8.5 days and at a mean volume of 1.5 ± 0.6 l per infusion. The mean change of the OHQ was 3.1 ± 0.3 (95% CI 2.6-3.7; P Conclusions Intermittent IV infusions of saline dramatically reduce symptoms and improve quality of life in patients suffering from POTS. Further work should explore its efficacy as a bridge study for patients of high s…
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Acute restoration of blood volume with intravenous saline or the vasopressin analog desmopressin attenuates standing heart rate and improves symptom burden in POTS.
“acute restoration of blood volume with either intravenous saline or the vasopressin analog desmopressin attenuates standing HR and improve symptom burden in these patients”
From Postural tachycardia syndrome – Diagnosis, physiology, and prognosis (2018) · cites this paper as Ruzieh et al., 2017
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- Authors
- Ruzieh, M., Baugh, A., Dasa, O., Parker, R. L., Perrault, J. T., Renno, A., Karabin, B. L., & Grubb, B.
- Affiliations
- University of Toledo Medical Center (US)
- University of Toledo (US)
- Corresponding author
- Ruzieh, Mohammed
- Venue
- Journal of Interventional Cardiac Electrophysiology
- Published
- 2017-02-09
- Volume
- 48
- Issue
- 3
- Pages
- 255-260
- ISSN
- 1383-875X (ISSN-L)
- 1572-8595
- OpenAlex
- W2587028156
- Cited by
- 48
- References
- 9
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 3 · 2015: 1
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Interventional Cardiac Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- postural orthostatic tachycardia syndrome, intravenous saline infusion, orthostatic intolerance, quality of life, orthostatic hypotension, symptom improvement, blood pooling
- MeSH terms
- Adult, Anti-Arrhythmia Agents, Dose-Response Relationship, Drug, Female, Fluid Therapy, Humans, Infusions, Intravenous, Male, Quality of Life, Sodium Chloride, Treatment Outcome, Patient Satisfaction, Treatment Failure, Postural Orthostatic Tachycardia Syndrome
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