The role of the inflammasome in nonmyeloid cells
Open accessAbstract
Inflammasomes are cytosolic multiprotein complexes that can proteolytically activate caspase-1. Activated caspase-1 is needed for the maturation and secretion of interleukin (IL)-1beta and IL-18. In the past decade, there has been tremendous progress in our knowledge of inflammasome function and IL-1 signaling, mainly in cells of the innate immune system, such as monocytes, macrophages, neutrophils, and dendritic cells. Because nonimmune cells, including keratinocytes, synovial cells, or astrocytes, can form an interface between the body and the environment or a defined compartment (brain, joint), they are important guardians for the detection of danger signals and the consecutive initiation of an inflammatory response. They are present in anatomical compartments that are less accessible to myeloid cells and thus can fulfill tasks usually performed by residential macrophages. This review focuses on recent progress in our understanding of the processing and functional role of IL-1 in epithelial, mesenchymal, and neuronal cells and in conditions such as tissue repair.
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Components of the inflammasome can be expressed in cell types other than macrophages that are involved in wound healing.
“Components of the inflammasome can be expressed in cell types other than Mp that are involved in wound healing (42).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [42]
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References 41 · Cited by 76
Research works printed but not linked: 2
- [19]19. Jin Y, Mailloux CM, Gowan K, et al. NALP1 in vitiligoassociated multiple autoimmune disease. N Engl J Med. 2007;356: 1216 -25.
- [18]18. experimental acute myocardial infarction. Circulation. 2008;117: 2670 -83.
- Authors
- Yazdi, A. S., Drexler, S. K., & Tschopp, J.
- Affiliations
- University of Lausanne (CH)
- Corresponding author
- Tschopp, Jürg
- ORCID
- Yazdi, Amir S.
- Venue
- Journal of Clinical Immunology
- Published
- 2010-06-27
- Volume
- 30
- Issue
- 5
- Pages
- 623-627
- ISSN
- 0271-9142 (ISSN-L)
- 1573-2592
- OpenAlex
- W2051836818
- Cited by
- 76
- References
- 41
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 10 · 2014: 5 · 2013: 10 · 2012: 3
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- green
- serval.unil.ch
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Journal of Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- reroDoc Digital Library (submittedVersion)
- IRIS (submittedVersion)
- Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- inflammasome, caspase-1, IL-1β, IL-18, epithelial cells, keratinocytes, synoviocytes, astrocytes, neurons, tissue repair, innate immunity, IL-1 signaling
- MeSH terms
- Animals, Cell Communication, Epithelial Cells, Humans, Immunity, Innate, Inflammation, Neurons, Signal Transduction, Mice, Interleukin-1beta, Inflammasomes, Mesenchymal Stem Cells
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