Cited by 114BRCA gene mutations in cancerCancer survivorship and careFamily Support in Illness

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Psychological Distress, Anxiety, and Depression of Cancer‐Affected BRCA1/2 Mutation Carriers: a Systematic Review

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Ringwald, Johanna, Wochnowski, Christina, Bosse, Kristin, Giel, Katrin Elisabeth, Schäffeler, Norbert, Zipfel, Stephan, Teufel, Martin·2016·Journal of Genetic Counseling

DOI 10.1007/s10897-016-9949-6

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Abstract

Understanding the intermediate‐ and long‐term psychological consequences of genetic testing for cancer patients has led to encouraging research, but a clear consensus of the psychosocial impact and clinical routine for cancer‐affected BRCA1 and BRCA2 mutation carriers is still missing. We performed a systematic review of intermediate‐ and long‐term studies investigating the psychological impact like psychological distress, anxiety, and depression in cancer‐affected BRCA mutation carriers compared to unaffected mutation carriers. This review included the screening of 1243 studies. Eight intermediate‐ and long‐term studies focusing on distress, anxiety, and depression symptoms among cancer‐affected mutation carriers at least six months after the disclosure of genetic testing results were included. Studies reported a great variety of designs, methods, and patient outcomes. We found evidence indicating that cancer‐affected mutation carriers experienced a negative effect in relation to psychological well‐being in terms of an increase in symptoms of distress, anxiety, and depression in the first months after test disclosure. In the intermediate‐ and long‐term, no significant clinical relevant symptoms occurred. However, none of the included studies used specific measurements, which can clearly identify psychological burdens of cancer‐affected mutation carriers. We concluded that current well‐implemented distress screening instruments are not sufficient for precisely identifying the psychological burden of genetic testing. Therefore, future studies should implement coping strategies, specific personality structures, the impact of genetic testing, supportive care needs and disease management behaviour to clearly screen for the possible intermediate‐ and long‐term psychological impact of a positive test disclosure.

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Authors: Ringwald, J., Wochnowski, C., Bosse, K., Giel, K. E., Schäffeler, N., Zipfel, S., & Teufel, M.
Affiliations: Universitätsklinikum Tübingen (DE)
Corresponding author: Ringwald, Johanna
ORCID: Giel, Katrin Elisabeth
Schäffeler, Norbert
Zipfel, Stephan
Teufel, Martin
Venue: Journal of Genetic Counseling
Publisher: Wiley
Published: 2016-04-14
Volume: 25
Issue: 5
Pages: 880-891
ISSN: 1059-7700 (ISSN-L)
1573-3599
DOI: 10.1007/s10897-016-9949-6
OpenAlex: W2340539776
Cited by: 114
References: 59
Citations by year: 2026: 10 · 2025: 14 · 2024: 7 · 2023: 20 · 2022: 15 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 10 · 2017: 4 · 2016: 3
FWCI: 1.11
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
www.springer.com/tdm (unspecified)
Locations: Journal of Genetic Counseling (publishedVersion)
PubMed (publishedVersion)
Funders: Athene programme, Ministry of Science Baden-Wuerttemberg and the European Social Fund
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Oncology › Cancer survivorship and care
Social Sciences › Psychology › Clinical Psychology › Family Support in Illness
Keywords: BRCA1 mutation carriers, BRCA2 mutation carriers, psychological distress, anxiety, depression, cancer patients, psychosocial impact, long-term mental health outcomes, coping strategies, supportive care needs
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Anxiety, Depression, Female, Genetic Testing, Humans, Longitudinal Studies, Male, Middle Aged, Mutation, Neoplasms, Stress, Psychological, BRCA1 Protein, BRCA2 Protein, Young Adult

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Psychological Distress, Anxiety, and Depression of Cancer‐Affected BRCA1/2 Mutation Carriers: a Systematic Review

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