The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Increased expression of CDK11p58 and cyclin D3 following spinal cord injury in rats
Abstract
Protein kinases are critical signalling molecules for normal cell growth and development. CDK11p58 is a p34cdc2-related protein kinase, and plays an important role in normal cell cycle progression. However its distribution and function in the central nervous system (CNS) lesion remain unclear. In this study, we mainly investigated the protein expression and cellular localization of CDK11 during spinal cord injury (SCI). Western blot analysis revealed that CDK11p58 was not detected in normal spinal cord. It gradually increased, reached a peak at 3 day after SCI, and then decreased. The protein expression of CDK11(p58) was further analyzed by immunohistochemistry. The variable immunostaining patterns of CDK11p58 were visualized at different periods of injury. Double immunofluorescence staining showed that CDK11 was co-expressed with NeuN, CNPase and GFAP. Co-localization of CDK11/active caspase-3 and CDK11/proliferating cell nuclear antigen (PCNA) were detected in some cells. Cyclin D3, which was associated with CDK11p58 and could enhance kinase activity, was detected in the normal and injured spinal cord. The cyclin D3 protein underwent a similar pattern with CDK11p58 during SCI. Double immunofluorescence staining indicated that CDK11 co-expressed with cyclin D3 in neurons and glial cells. Coimmunoprecipitation further showed that CDK11p58 and cyclin D3 interacted with each other in the damaged spinal cord. Thus, it is likely CDK11p58 and cyclin D3 could interact with each oth…
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“In fact, available evidence indicates that EZH2, E2F2, E2F3, and CCND3 become upregulated in the damaged spinal cord [90,91,92] and induce neuronal death during SCI’s secondary damage [9,90,93].”
From MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord (2022) · cites this paper as [92]
Citations
Cites
Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage
Kruman, I. I., Wersto, R. P., Cardozo‐Pelaez, F., Smilenov, L. B., Chan, S. L., Chrest, F. J., Emokpae, R., Gorospe, M., & Mattson, M. P. (2004) · Neuron · doi:10.1016/s0896-6273(04)00017-0 · Cited by 371
Identification and Characterization of a Novel Cell Cycle–Regulated Internal Ribosome Entry Site
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Gene profiling in spinal cord injury shows role of cell cycle in neuronal death
Giovanni, S. D., Knoblach, S. M., Brandoli, C., Aden, S. A., Hoffman, E. P., & Faden, A. I. (2003) · Annals of Neurology · doi:10.1002/ana.10472 · Cited by 275
Role of Cell Cycle Regulatory Proteins in Cerebellar Granule Neuron Apoptosis
Padmanabhan, J., Park, D. S., Greene, L. A., & Shelanski, M. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08747.1999 · Cited by 233
PITSLRE protein kinase activity is associated with apoptosis
Lahti, J. M., Xiang, J., Heath, L. S., Campana, D., & Kidd, V. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.1 · Cited by 210
Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.
Bunnell, B. A., Heath, L. S., Adams, D. E., et al. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7467 · Cited by 152
Purification and characterization of human RNPS1: a general activator of pre‐mRNA splicing
Mayeda, A., Badolato, J., Kobayashi, R., Zhang, M. Q., Gardiner, E. M., & Krainer, A. R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.16.4560 · Cited by 147
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The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation
Petretti, C., Savoian, M. S., Montembault, É., Glover, D. M., Prigent, C., & Giet, R. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400639 · Cited by 134
Cyclin L Is an RS Domain Protein Involved in Pre-mRNA Splicing
Dickinson, L. A., Edgar, A. J., Ehley, J. A., & Gottesfeld, J. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202266200 · Cited by 124
Cited by
Maza, R. M., Barreda-Manso, M. A., Reigada, D., Silván, Á., Muñoz-Galdeano, T., Soto, A., del Águila, Á., & Nieto-Díaz, M. (2022) · Biomedicines · doi:10.3390/biomedicines10071559 · Cited by 12
Metadata
- Authors
- Ji, Y., Xiao, F., Sun, L., Qin, J., Shi, S., Yang, J., Liu, Y., Zhou, D., Zhao, J., & Shen, A.
- Venue
- Molecular and Cellular Biochemistry
- Published
- 2007-11-16
- Volume
- 309
- Issue
- 1-2
- Pages
- 49-60
- ISSN
- 0300-8177
- 1573-4919
- Cited by
- 12
- References
- 40
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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