Newly identified tumor-associated role of human Sharpin
Abstract
In order to discover previously unidentified cancer-associated genes, we analyzed genome-wide differences in gene expression between tumor biopsies and normal tissues. Among those differentially regulated genes, we identified Sharpin (Shank-associated RH domain-interacting protein) as a commonly up-regulated gene in multiple human cancer types. Although rat Sharpin is reported to interact with Shank1, a multidomain scaffold protein localized in postsynaptic densities, its exact roles are unknown. Whereas human Sharpin homologue was primarily localized in the cytosol of cultured cells, they were detected in both cytosol and nucleus of the cells from ovarian and liver cancer tissues using immunohistochemical staining. In addition, Chinese ovary hamster cells over-expressing Sharpin exhibited enhanced cancer-specific phenotypes in multiple in vitro tumor assays. Taken together, the results suggest that Sharpin is not an inert scaffold protein, but may play tumor-associated roles during cancer biogenesis.
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SHARPIN is a cytoplasmic adaptor protein involved in the regulation of multiple cellular functions.
“SHANK-associated RH domain interactor (SHARPIN) is mainly a cytoplasmic adaptor protein involved in the regulation of multiple cellular functions”
From SHARPIN S146 phosphorylation mediates ARP2/3 interaction, cancer cell invasion and metastasis (2022) · cites this paper as Jung, Kim et al., 2010
Cites
Transcription factors as targets for cancer therapy
Darnell, J. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc906 · Cited by 1,194 · see citing works
Lim, S., Sala, C., Yoon, J., Park, S., Kuroda, S., Sheng, M., & Kim, E. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0940 · Cited by 151 · see citing works
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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S.-I., Tanaka, K., Nakano, H., & Iwai, K. (2011) · Nature · doi:10.1038/nature09815 · Cited by 609 · see citing works
SHARPIN S146 phosphorylation mediates ARP2/3 interaction, cancer cell invasion and metastasis
Butt, U., Khan, M. H., Pouwels, J., & Westermarck, J. (2022) · Journal of Cell Science · doi:10.1242/jcs.260627 · Cited by 6 · see citing works
SHARPIN serine 146 phosphorylation mediates ARP2/3 interaction, cancer cell invasion and metastasis
Butt, U., Khan, M. H., Pouwels, J., & Westermarck, J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.21.477220 · Cited by 6 · see citing works
“S1A) (Bii et al., 2015, De Melo & Tang, 2015, He et al., 2010, Jung et al., 2010).”
- Authors
- Jung, J., Kim, J. M., Park, B., Cheon, Y., Lee, B., Choo, S. H., Koh, S. S., & Lee, S.
- Affiliations
- Chungnam National University (KR)
- LG (South Korea) (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Corresponding author
- Lee, Soojin
- Venue
- Molecular and Cellular Biochemistry
- Published
- 2010-02-24
- Volume
- 340
- Issue
- 1-2
- Pages
- 161-167
- ISSN
- 0300-8177 (ISSN-L)
- 1573-4919
- OpenAlex
- W2023597476
- Cited by
- 59
- References
- 2
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 9 · 2016: 2 · 2015: 6 · 2014: 5 · 2013: 2 · 2012: 4
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular and Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- KRIBB Repository (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- SHARPIN, cancer genes, gene expression profiling, tumor biopsy, ovarian cancer, liver cancer, nuclear localization, cytosolic localization, tumor promotion, scaffold proteins
- MeSH terms
- Animals, Biopsy, Cell Movement, Cell Transformation, Neoplastic, Cloning, Molecular, Cricetulus, Cricetinae, Humans, Immunohistochemistry, Neoplasms, Nerve Tissue Proteins, Time Factors, Transfection, Up-Regulation, Gene Expression Regulation, Neoplastic, CHO Cells, Gene Expression Profiling, Cell Proliferation, Genetic Association Studies
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