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Croatian national reference Y-STR haplotype database

Mršić, Gordan, Gršković, Branka, Vrdoljak, Andro, Popović, Maja, Valpotić, Ivica, Anđelinović, Šimun, Stenzl, Vlastimil, Ehler, Edvard, Urban, Ludvik, Lacković, Gordana, Underhill, Peter, Primorac, Dragan·2012·Molecular Biology Reports

Abstract

A reference Y-chromosome short tandem repeat (STR) haplotype database is needed for Y-STR match interpretation as well as for national and regional characterization of populations. The aim of this study was to create a comprehensive Y-STR haplotype database of the Croatian contemporary population and to analyze substructure between the five Croatian regions. We carried out a statistical analysis of the data from previously performed genetic analyses collected during routine forensic work by the Forensic Science Centre "Ivan Vučetić". A total of 1,100 unrelated men from eastern, western, northern, southern and central Croatia were selected for the purpose of this study. Y-STRs were typed using the AmpFISTR Yfiler PCR amplification kit. Analysis of molecular variance calculated with the Y chromosome haplotype reference database online analysis tool included 16 population samples with 20,247 haplotypes. A total of 947 haplotypes were recorded, 848 of which were unique (89.5%). Haplotype diversity was 0.998, with the most frequent haplotype found in 9 of 1,100 men (0.82%). Locus diversity varied from 0.266 for DYS392 to 0.868 for DYS385. Discrimination capacity was 86.1%. Our results suggested high level of similarity among regional subpopulations within Croatia, except for mildly different southern Croatia. Relative resemblance was found with Bosnia and Herzegovina and Serbia. Whit Atheys' Haplogroup Predictor was used to estimate the frequencies of Y-chromosome haplogroups. I2a…

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Cited by

Metadata

Authors
Mršić, G., Gršković, B., Vrdoljak, A., Popović, M., Valpotić, I., Anđelinović, Š., Stenzl, V., Ehler, E., Urban, L., Lacković, G., Underhill, P., & Primorac, D.
Venue
Molecular Biology Reports
Published
2012-03-06
Volume
39
Issue
7
Pages
7727-7741
ISSN
  • 0301-4851
  • 1573-4978
Cited by
11
References
0
Language
en

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