PEG-stearate coated solid lipid nanoparticles as levothyroxine carriers for oral administration
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LT4-loaded PEG stearate coated solid lipid nanoparticles remained stable in the gastric environment and showed a gradual release of drug up to 60 hours in vitro.
“Although the particles remained stable in the gastric environment and showed a gradual release of drug up to 60 hours in vitro, there were some unneglectable flaws to address.”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [275]
Only 70% of total LT4 was able to be released from the nanoparticles.
“Moreover, only 70% of total LT4 was able to be released from nanoparticles.”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [275]
A 40% to 50% burst release of total contents was observed in the first 12 hours.
“A 40% to 50% burst release of total contents was observed in the first 12 hours.”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [275]
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References 57 · Cited by 28
- Authors
- Kashanian, S., & Rostami, E.
- Affiliations
- Razi University (IR)
- Shiraz University (IR)
- Corresponding author
- Kashanian, Soheila
- Venue
- Journal of Nanoparticle Research
- Published
- 2014-02-27
- Volume
- 16
- Issue
- 3
- ISSN
- 1388-0764 (ISSN-L)
- 1572-896X
- OpenAlex
- W2077344570
- Cited by
- 28
- References
- 57
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 1
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Nanoparticle Research (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- solid lipid nanoparticles, levothyroxine sodium, oral drug delivery, microemulsification, zeta potential, encapsulation efficiency, amorphous drug loading, gastric stability, controlled drug release, nanoparticle aggregation
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