Regression in Autistic Spectrum Disorders
Abstract
A significant proportion of children diagnosed with Autistic Spectrum Disorder experience a developmental regression characterized by a loss of previously-acquired skills. This may involve a loss of speech or social responsitivity, but often entails both. This paper critically reviews the phenomena of regression in autistic spectrum disorders, highlighting the characteristics of regression, age of onset, temporal course, and long-term outcome. Important considerations for diagnosis are discussed and multiple etiological factors currently hypothesized to underlie the phenomenon are reviewed. It is argued that regressive autistic spectrum disorders can be conceptualized on a spectrum with other regressive disorders that may share common pathophysiological features. The implications of this viewpoint are discussed.
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Rates of parent-reported regression vary depending on how stringent a definition is employed.
“A recent meta-analysis suggested a mean prevalence of parentreported regression of 32% (Barger et al. 2013), but rates vary depending on how stringent a definition is employed (Hansen et al. 2008, Stefanatos 2008).”
From Recent Advances in Autism Research as Reflected in DSM-5 Criteria for Autism Spectrum Disorder (2015) · cites this paper as Stefanatos 2008
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References 123 · Cited by 161
- Authors
- Stefanatos, G. A.
- Affiliations
- Temple University (US)
- Corresponding author
- Stefanatos, Gerry A.
- Venue
- Neuropsychology Review
- Published
- 2008-10-28
- Volume
- 18
- Issue
- 4
- Pages
- 305-319
- ISSN
- 1040-7308 (ISSN-L)
- 1573-6660
- OpenAlex
- W2078191764
- Cited by
- 161
- References
- 123
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 12 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 9 · 2015: 11 · 2014: 15 · 2013: 15 · 2012: 17
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychology Review (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, developmental regression, regressive autism, speech loss, age of onset, long-term outcomes, etiology, pathophysiology
- MeSH terms
- Autistic Disorder, Environment, Humans, Regression, Psychology, Sex Characteristics, Social Behavior, Prevalence
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