Trigonelline and related nicotinic acid metabolites: occurrence, biosynthesis, taxonomic considerations, and their roles in planta and in human health
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Trigonelline is a natural alkaloid found in plants and animals, including humans.
“However, patients with sarcopenia had lower circulating concentrations of trigonelline, a natural alkaloid found in plants4 and animals, including in humans29,30 (Fig. 1a).”
From Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia (2024) · cites this paper as [4]
Its synthesis from NA via methylation confers protective and adaptive functions, without an established reutilization as a Preiss-Handler substrate.
“Its synthesis from NA via methylation confers protective and adaptive functions4,48, without an established reutilization as a Preiss–Handler substrate49,50.”
From Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia (2024) · cites this paper as [4]
Trigonelline is particularly abundant in plant-derived food products, such as coffee beans and fenugreek seeds, which have been reported to modulate endogenous trigonelline levels in humans.
“trigonelline is particularly abundant in plant-derived food products, such as coffee beans and fenugreek seeds, which have been reported to modulate endogenous trigonelline levels in humans4,51,52.”
From Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia (2024) · cites this paper as [4]
The citation lists haven’t been fetched yet
References 200 · Cited by 110
- Authors
- Ashihara, H., Ludwig, I. A., Katahira, R., Yokota, T., Fujimura, T., & Crozier, A.
- Affiliations
- Ochanomizu University (JP)
- University of Glasgow (GB)
- Kobe Shoin Women's University (JP)
- Teikyo University (JP)
- University of Tsukuba (JP)
- Corresponding author
- Ashihara, Hiroshi
- Venue
- Phytochemistry Reviews
- Published
- 2014-08-17
- Volume
- 14
- Issue
- 5
- Pages
- 765-798
- ISSN
- 1568-7767 (ISSN-L)
- 1572-980X
- OpenAlex
- W1995641409
- Cited by
- 110
- References
- 200
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 14 · 2023: 15 · 2022: 14 · 2021: 7 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 5
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Phytochemistry Reviews (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- trigonelline, pyridine alkaloids, pyridine nucleotide biosynthesis, NAD+ degradation, plant secondary metabolites, coffee beans, Fabaceae, plant detoxification, nyctinasty, host selection, hypoglycemic activity, neuroprotection, anticancer activity, estrogenic activity, antibacterial activity, nicotinic acid, genetically modified crops, plant genetic engineering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
