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Cited by 1Phytochemicals and Antioxidant ActivitiesPhytochemistry and Biological ActivitiesCoffee research and impacts

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Caffeoylquinic acids: structural diversity, biosynthesis, isomer-resolved analysis, and structure-dependent bioactivities

Xiao, Yiming, Shi, Yun, Zhang, Jiaojiao, Xu, Nuo, Liu, Chunhui, Zhang, Chenfeng, Gao, Xun, Zhou, Xunyong, Qin, Kunming·2026·Phytochemistry Reviews
DOI 10.1007/s11101-026-10280-4
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  1. Albrecht C, Cittadini MC, Soria EA (2020) Pharmacological activity of quercetin and 5 caffeoylquinic acid oral intake in male Balb/c mice with lung adenocarcinoma. Arch Med Res 51(1):8–12. https://doi.org/10.1016/j.arcmed.2019.11.006 · DOI
  2. Alcazar Magana A, Kamimura N, Soumyanath A, Stevens JF, Maier CS (2021) Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity. Plant J 107(5):1299–1319. https://doi.org/10.1111/tpj.15390 · DOI
  3. Bakr RO, Shahat EA, Elissawy AE, Fayez AM, Eldahshan OA (2021) Evaluation of the hepatoprotective activity of Pulicaria incisa subspecies candolleana and in silico screening of its isolated phenolics. J Ethnopharmacol 271:113767. https://doi.org/10.1016/j.jep.2020.113767 · DOI
  4. Bejaoui M, Villareal MO, Isoda H (2020) 3,4,5-Tri-O-caffeoylquinic acid promoted hair pigmentation through β-catenin and its target genes. Front Cell Dev Biol. https://doi.org/10.3389/fcell.2020.00175 · DOI
  5. Bejaoui A, M’rabet Y, Boulila A (2024) Caffeoylquinic acid derivatives: chemical diversity and effect on the oxidative stress-related pathologies. Chem Afr 7(8):4105–4126. https://doi.org/10.1007/s42250-024-00985-4 · DOI
  6. Bellumori M, Pallecchi M, Zonfrillo B, Lucio L, Menicatti M, Innocenti M, Mulinacci N, Bartolucci G (2023) Study of mono and Di-O-caffeoylquinic acid isomers in acmella oleracea extracts by HPLC-MS/MS and application of linear equation of deconvolution analysis algorithm for their characterization. Pharmaceuticals. https://doi.org/10.3390/ph16101375 · DOI
  7. Boulebd H, Carmena-Bargueño M, Pérez-Sánchez H (2023) Exploring the antioxidant properties of caffeoylquinic and feruloylquinic acids: a computational study on hydroperoxyl radical scavenging and xanthine oxidase inhibition. Antioxidants. https://doi.org/10.3390/antiox12091669 · DOI
  8. Chen X, Yang JH, Cho SS, Kim JH, Xu J, Seo K, Ki SH (2020) 5-Caffeoylquinic acid ameliorates oxidative stress-mediated cell death via Nrf2 activation in hepatocytes. Pharm Biol 58(1):999–1005. https://doi.org/10.1080/13880209.2020.1818791 · DOI
  9. Cortez N, Villegas C, Burgos V, Ortiz L, Cabrera-Pardo JR, Paz C (2024) Therapeutic potential of chlorogenic acid in chemoresistance and chemoprotection in cancer treatment. Int J Mol Sci. https://doi.org/10.3390/ijms25105189 · DOI
  10. Custódio L, Cziáky Z, Castañeda-Loaiza V, Rodrigues MJ (2024) Establishment and elicitation of liquid adventitious root cultures of Inula crithmoides L. for increased caffeoylquinic acids production and hepatoprotective properties. Plant Cell Tissue Organ Cult (PCTOC). https://doi.org/10.1007/s11240-024-02690-z · DOI
  11. D’Orso F, Hill L, Appelhagen I, Lawrenson T, Possenti M, Li J, Harwood W, Morelli G, Martin C (2023) Exploring the metabolic and physiological roles of HQT in S lycopersicum by gene editing. Front Plant Sci. https://doi.org/10.3389/fpls.2023.1124959 · DOI
  12. Dai Y, Dou Z, Zhou R, Luo L, Bian L, Chen Y, Tao J, Chen Z, Herrero Hernandez E (2021) Quality evaluation of Artemisia capillaris Thunb. Based on qualitative analysis of the HPLC fingerprint and UFLC-Q-TOF-MS/MS combined with quantitative analysis of multicomponents. J Anal Methods Chem 2021:1–13. https://doi.org/10.1155/2021/5546446 · DOI
  13. Dall’Acqua S, Sut S, Sinan KI, Zengin G, Ferrarese I, Peron G, Yildiztugay E, Picot-Allain C, Mahomoodally MF (2022) An Integrated NMR, LC-DAD-MS LC-QTOF metabolomic characterization of Sartoria hedysaroides: correlation of antioxidant and enzyme inhibitory activity with chemical composition by multivariate data analysis. Antioxidants (Basel). https://doi.org/10.3390/antiox11010110 · DOI
  14. Delnavazi M-R, Etemadi-Tajbakhsh N, Faramarzi M-A (2020) 1, 5-dicaffeoylquinic acid, an α-glucosidase inhibitor from the root of Dorema ammoniacum D. Don. Res Pharm Sci. https://doi.org/10.4103/1735-5362.297845 · DOI
  15. Diemer E, Chadni M, Grimi N, Ioannou I (2022) Optimization of the accelerated solvent extraction of caffeoylquinic acids from forced chicory roots and antioxidant activity of the resulting extracts. Foods. https://doi.org/10.3390/foods11203214 · DOI
  16. El Din RH, Thabit S (2024) Quinic acid protects against the development of Huntington’s disease in Caenorhabditis elegans model. BMC Complement Med Therap. https://doi.org/10.1186/s12906-024-04670-4 · DOI
  17. Engelhardt L, Pöhnl T, Neugart S (2021) Interactions of ascorbic acid, 5-caffeoylquinic acid, and quercetin-3-rutinoside in the presence and absence of iron during thermal processing and the influence on antioxidant activity. Molecules. https://doi.org/10.3390/molecules26247698 · DOI
  18. Ernawati, Suryadi, H., & Mun'im, A. (2021). Effect of gamma irradiation on the caffeoylquinic acid derivatives content, antioxidant activity, and microbial contamination of Pluchea indica leaves. Heliyon, https://doi.org/10.1016/j.heliyon.2021.e07825 · DOI
  19. Ge L, Wan H, Tang S, Chen H, Li J, Zhang K, Zhou B, Fei J, Wu S, Zeng X (2018) Novel caffeoylquinic acid derivatives from Lonicera japonica. Thunb flower buds exert pronounced anti-HBV activities. RSC Adv 8(62):35374–35385. https://doi.org/10.1039/c8ra07549b · DOI
  20. Harsha Haridas ES, Bhattacharya S, Varma MKR, Chandra GK (2023) Bioinspired 5-caffeoylquinic acid capped silver nanoparticles using Coffee arabica leaf extract for high-sensitive cysteine detection. Sci Rep. https://doi.org/10.1038/s41598-023-34944-9 · DOI
  21. Huang Y, Xu W, Dong W, Chen G, Sun Y, Zeng X (2025) Anti-diabetic effect of dicaffeoylquinic acids is associated with the modulation of gut microbiota and bile acid metabolism. J Adv Res 72:17–35. https://doi.org/10.1016/j.jare.2024.06.027 · DOI
  22. Hufnagel M, Rademaekers A, Weisert A, Häberlein H, Franken S (2024) Pharmacological profile of dicaffeoylquinic acids and their role in the treatment of respiratory diseases. Front Pharmacol. https://doi.org/10.3389/fphar.2024.1371613 · DOI
  23. Imai M, Yamane T, Kozuka M, Takenaka S, Sakamoto T, Ishida T, Nakagaki T, Nakano Y, Inui H (2020) Caffeoylquinic acids from aronia juice inhibit both dipeptidyl peptidase IV and α-glucosidase activities. Lwt. https://doi.org/10.1016/j.lwt.2020.109544 · DOI
  24. Jang G, Lee S, Hong J, Park B, Kim D, Kim C (2021) Anti-inflammatory effect of 4,5-dicaffeoylquinic acid on RAW264.7 cells and a rat model of inflammation. Nutrients. https://doi.org/10.3390/nu13103537 · DOI
  25. Jang G, Lee SA, Hong JH, Park B-R, Kim DK, Kim CS (2022) Chondroprotective effects of 4,5-dicaffeoylquinic acid in osteoarthritis through NF-κB signaling inhibition. Antioxidants. https://doi.org/10.3390/antiox11030487 · DOI
  26. Jangid K, Mahto JK, Kumar KA, Dhaka P, Sharma A, Tariq A, Sharma AK, Kumar P (2025) Structural and biochemical analyses reveal quinic acid inhibits DAHP synthase a key player in shikimate pathway. Arch Biochem Biophys. https://doi.org/10.1016/j.abb.2024.110219 · DOI
  27. Kamarauskaite J, Baniene R, Raudone L, Vilkickyte G, Vainoriene R, Motiekaityte V, Trumbeckaite S (2021) Antioxidant and Mitochondria-targeted activity of caffeoylquinic-acid-rich fractions of wormwood (Artemisia absinthium L.) and silver wormwood (Artemisia ludoviciana Nutt.). Antioxidants. https://doi.org/10.3390/antiox10091405 · DOI
  28. Lemos MF, de Andrade Salustriano N, de Souza Costa MM, Lirio K, da Fonseca AFA, Pacheco HP, Endringer DC, Fronza M, Scherer R (2022) Chlorogenic acid and caffeine contents and anti-inflammatory and antioxidant activities of green beans of conilon and arabica coffees harvested with different degrees of maturation. J Saudi Chem Soc. https://doi.org/10.1016/j.jscs.2022.101467 · DOI
  29. Li J, Dou L, Chen S, Zhou H, Mou F (2021a) Neochlorogenic acid: an anti-HIV active compound identified by screening of Cortex Mori [Morus Alba L. (Moraceae)]. Pharm Biol 59(1):1517–1527. https://doi.org/10.1080/13880209.2021.1995005 · DOI · Paper page
  30. Li R, Tao M, Wu T, Zhuo Z, Xu T, Pan S, Xu X (2021b) A promising strategy for investigating the anti-aging effect of natural compounds: a case study of caffeoylquinic acids. Food Funct 12(18):8583–8593. https://doi.org/10.1039/d1fo01383a · DOI
  31. Li L, Qiu Z, Jiang M, Zhang B, Chen Q, Zhang C, Zheng Z, Qiao X (2022) Visualizing the spatial distribution of Arctium lappa L. Root components by MALDI-TOF mass spectrometry imaging. Foods 11(24):11. https://doi.org/10.3390/foods11243957 · DOI
  32. Li K, Feng Z, Wang L, Ma X, Wang L, Liu K, Geng X, Peng C (2023a) Chlorogenic acid alleviates hepatic ischemia-reperfusion injury by inhibiting oxidative stress, inflammation, and mitochondria-mediated apoptosis in vivo and in vitro. Inflammation 46(3):1061–1076. https://doi.org/10.1007/s10753-023-01792-8 · DOI
  33. Li Z, Zhang J, Meng Q, Yang L, Qiu M, Li Y, Yao S, Wei W, Yao C, Bi Q, Li J, Guo DA (2023b) The content and distribution of 18 phenolic compounds in 462 batches of edible flowers from 73 species commercially available in China. Food Res Int 166:112590. https://doi.org/10.1016/j.foodres.2023.112590 · DOI
  34. Li F, Hou H, Zhao T, Song G, Wang D, Yuan T, Li L, Gong J (2025) Revealing the non-enzymatic covalent interaction between neo−/crypto-chlorogenic acid and beta-lactoglobulin under nonthermal process and potential delivery capability. Food Chem. https://doi.org/10.1016/j.foodchem.2025.143325 · DOI
  35. Lim DW, Kim M, Yoon M, Lee J, Lee C, Um MY (2021) 1,3-Dicaffeoylquinic acid as an active compound of arctium lappa root extract ameliorates depressive-like behavior by regulating hippocampal nitric oxide synthesis in ovariectomized mice. Antioxidants. https://doi.org/10.3390/antiox10081281 · DOI
  36. Liu W, Li J, Zhang X, Zu Y, Yang Y, Liu W, Xu Z, Gao H, Sun X, Jiang X, Zhao Q (2020) Current advances in naturally occurring caffeoylquinic acids: structure, bioactivity, and synthesis. J Agric Food Chem 68(39):10489–10516. https://doi.org/10.1021/acs.jafc.0c03804 · DOI
  37. Liu J, Chen J, Xu B, Lin L, Liu S, Ma X, Liu J (2022a) 3,4,5-O-tricaffeoylquinic acid with anti-radiation activity suppresses LPS-induced NLRP3 inflammasome activation via autophagy in THP-1 macrophages. Mol Immunol 147:187–198. https://doi.org/10.1016/j.molimm.2022.05.011 · DOI
  38. Liu J, Song G, Yuan Y, Zhou L, Wang D, Yuan T, Li L, He G, Yang Q, Xiao G, Gong J (2022b) Ultrasound-assisted assembly of β-lactoglobulin and chlorogenic acid for non covalent nanocomplex: fabrication, characterization and potential biological function. Ultrason Sonochem. https://doi.org/10.1016/j.ultsonch.2022.106025 · DOI
  39. Liu Y, Zhong X, Lin S, Xu H, Liang X, Wang Y, Xu J, Wang K, Guo X, Wang J, Yu M, Li C, Xie C (2022c) Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders. Microbiome. https://doi.org/10.1186/s40168-022-01430-9 · DOI
  40. Liu J, Song G, Zhou L, Wang D, Yuan T, Li L, He G, Xiao G, Gong J (2023a) Comparison of non-covalent binding interactions of six caffeoylquinic acids with β-lactoglobulin: spectroscopic analysis, molecular docking and embedding of curcumin. Food Hydrocol. https://doi.org/10.1016/j.foodhyd.2022.108391 · DOI
  41. Liu S, Li X, Cai R, Chen B, Zeng J, Li C, Zhou X, Li Y (2023b) Ultra-high-performance liquid chromatography-Quadrupole-Exactive-Orbitrap-tandem mass spectrometry-based putative identification for Eucommiae Folium (Duzhongye) and its quality-marker candidate for pharmacopeia. J Sep Sci 46(13):e2300041. https://doi.org/10.1002/jssc.202300041 · DOI
  42. Loaiza-Campiño I, Villegas-Hincapié A, Arana V, Posada H (2020) Characterization of chlorogenic acids (CGA) and nine isomers in an F2 population derived from Coffea arabica L. Agronomía Colombiana 38(1):19–28. https://doi.org/10.15446/agron.colomb.v38n1.74338 · DOI
  43. Lu H, Tian Z, Cui Y, Liu Z, Ma X (2020) Chlorogenic acid: a comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions. Compr Rev Food Sci Food Saf 19(6):3130–3158. https://doi.org/10.1111/1541-4337.12620 · DOI
  44. Lu C-W, Lin T-Y, Hsieh PW, Chiu K-M, Lee M-Y, Wang S-J (2023) Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Neurochem Int. https://doi.org/10.1016/j.neuint.2023.105537 · DOI
  45. Lu C, Yan X, Zhang H, Zhong T, Gui A, Liu Y, Pan L, Shao Q (2024) Integrated metabolomic and transcriptomic analysis reveals biosynthesis mechanism of flavone and caffeoylquinic acid in chrysanthemum. BMC Genom 25(1):759. https://doi.org/10.1186/s12864-024-10676-6 · DOI
  46. Maciel G, Lopes AA, Cantrell CL, de Castro França S, Bertoni BW, Lourenço MV (2021) Jasmonates promote enhanced production of bioactive caffeoylquinic acid derivative in Eclipta prostrata (L.) L. hairy roots. Plant Cell Tissue Organ Cult (PCTOC) 149(1–2):363–369. https://doi.org/10.1007/s11240-021-02201-4 · DOI
  47. Márquez-Domínguez L, Jasso-Miranda C, Sedeño-Monge V, Santos-López G (2024) Non-analog compounds to sialic acid as inhibitors of influenza virus neuraminidase: an underexplored approach for novel antivirals-systematic review. Sci Pharm. https://doi.org/10.3390/scipharm92020033 · DOI
  48. Meinhart AD, Damin FM, Caldeirão L, de Jesus Filho M, da Silva LC, da Silva Constant L, Teixeira Filho J, Wagner R, Teixeira Godoy H (2019) Study of new sources of six chlorogenic acids and caffeic acid. J Food Compos Anal. https://doi.org/10.1016/j.jfca.2019.103244 · DOI
  49. Moglia A, Lanteri S, Comino C, Hill L, Knevitt D, Cagliero C, Rubiolo P, Bornemann S, Martin C (2014) Dual catalytic activity of hydroxycinnamoyl-coenzyme a quinate transferase from tomato allows it to moonlight in the synthesis of both mono- and dicaffeoylquinic acids. Plant Physiol 166(4):1777–1787. https://doi.org/10.1104/pp.114.251371 · DOI
  50. Morais MG, Saldanha AA, Mendes IC, Rodrigues JPC, Azevedo LS, Ferreira LM, Amado PA, Zanuncio VSS, Farias KS, Silva DB, Pinto FCH, Soares AC, Lima L (2024) Antinociceptive and anti-inflammatory potential, and chemical characterization of the dichloromethane fraction of Solanum lycocarpum (Solanaceae) ripe fruits by LC-DAD-MS. J Ethnopharmacol 322:117640. https://doi.org/10.1016/j.jep.2023.117640 · DOI
  51. Park J, Kim Y, Lee C, Kim YT (2022) 3,5-Dicaffeoylquinic acid attenuates microglial activation-mediated inflammatory pain by enhancing autophagy through the suppression of MCP3/JAK2/STAT3 signaling. Biomed Pharmacother. https://doi.org/10.1016/j.biopha.2022.113549 · DOI
  52. Ruano-González A, Pinto AA, Chinchilla N, Palma M, Barbero GF, Carrera C, Vázquez-Espinosa M (2023) Determination of caffeoylquinic acids content by UHPLC in scolymus hispanicus extracts obtained through ultrasound-assisted extraction. Plants. https://doi.org/10.3390/plants12122340 · DOI
  53. Sabaragamuwa R, Perera CO, Fedrizzi B (2022) Ultrasound assisted extraction and quantification of targeted bioactive compounds of Centella asiatica (Gotu Kola) by UHPLC-MS/MS MRM tandem mass spectroscopy. Food Chem. https://doi.org/10.1016/j.foodchem.2021.131187 · DOI
  54. Shafaghatlonbar M, Bagherzade G (2023) Dual role of chlorogenic acid as an influential precursor in synthesizing nano-sized Cu(II) complexes and investigating its catalytic role in the oxidation of alcohols and its antibacterial activity. J Organomet Chem. https://doi.org/10.1016/j.jorganchem.2023.122758 · DOI
  55. Shah M-A, Kang J-B, Park D-J, Kim M-O, Koh P-O (2022) Chlorogenic acid alleviates cerebral ischemia-induced neuroinflammation via attenuating nuclear factor kappa B activation. Neurosci Lett. https://doi.org/10.1016/j.neulet.2022.136495 · DOI
  56. Siegwart M, Gauffre B, Lecerf E, Poessel JL (2024) Efficacy of 2 botanical aphicides, chicoric and 3,5-dicaffeoylquinic acids, on aphids susceptible and resistant to synthetic insecticides. J Econ Entomol 117(4):1347–1355. https://doi.org/10.1093/jee/toae069 · DOI
  57. Singh S, Varshney M (2024) Exploring the pharmacological potential of chlorogenic acid as an anti-cancer agent and a call for advance research. Comb Chem High Throughput Screen. https://doi.org/10.2174/0113862073321017240610060637 · DOI
  58. Skala E, Olszewska MA, Tabaka P, Kicel A (2024) Light-emitting diodes and liquid system affect the caffeoylquinic acid derivative and flavonoid production and shoot growth of Rhaponticum carthamoides (Willd.) Iljin. Molecules. https://doi.org/10.3390/molecules29092145 · DOI
  59. Son S-R, Kim KS, Jang DS, Lee S (2025) Caffeoylglucaric and caffeoylquinic acids from inula japonica leaves and their anti-skin aging effects in TNF-α-induced normal human fibroblast damage. J Agric Food Chem 73(22):13471–13487. https://doi.org/10.1021/acs.jafc.4c13160 · DOI
  60. Song G, Li F, Shi X, Liu J, Cheng Y, Wu Y, Fang Z, Zhu Y, Wang D, Yuan T, Cai R, Li L, Gong J (2024) Characterization of ultrasound-assisted covalent binding interaction between β-lactoglobulin and dicaffeoylquinic acid: great potential for the curcumin delivery. Food Chem. https://doi.org/10.1016/j.foodchem.2024.138400 · DOI
  61. Sreedharan S, Nair V, Bhargava P, Cisneros-Zevallos L (2025) Protective role of polyphenols from aronia berry (Aronia melanocarpa) against LPS-induced inflammation in colon cells and macrophages. Nutrients 17(10):1652 · DOI
  62. Szliszka E, Czuba ZP, Domino M, Mazur B, Zydowicz G, Krol W (2009) Ethanolic extract of propolis (EEP) enhances the apoptosis- inducing potential of TRAIL in cancer cells. Molecules 14(2):738–754. https://doi.org/10.3390/molecules14020738 · DOI
  63. Tang S, Zhong W, Li T, Li Y, Song G (2023) Isochlorogenic acid A alleviates dextran sulfate sodium-induced ulcerative colitis in mice through STAT3/NF-кB pathway. Int Immunopharmacol. https://doi.org/10.1016/j.intimp.2023.109989 · DOI
  64. Tosovic J, Markovic S, Dimitric Markovic JM, Mojovic M, Milenkovic D (2017) Antioxidative mechanisms in chlorogenic acid. Food Chem 237:390–398. https://doi.org/10.1016/j.foodchem.2017.05.080 · DOI
  65. Wan C, Li S, Liu L, Chen C, Fan S (2017) Caffeoylquinic acids from the aerial parts of chrysanthemum coronarium L. Plants. https://doi.org/10.3390/plants6010010 · DOI
  66. Wan H, Ge L, Xiao L, Li J, Wu W, Peng S, Huang J, Zhou B, Zeng X (2020) 3,4,5-Tri-O-caffeoylquinic acid methyl ester isolated from Lonicera japonica Thunb. Flower buds facilitates hepatitis B virus replication in HepG2.2.15 cells. Food Chem Toxicol. https://doi.org/10.1016/j.fct.2020.111250 · DOI
  67. Wang D, Liu J, Qiu S, Wang J, Song G, Chu B, Li L, Xiao G, Gong J, Zheng F (2021) Ultrasonic degradation kinetics and isomerization of 3- and 4-O-caffeoylquinic acid at various pH: the protective effects of ascorbic acid and epigallocatechin gallate on their stability. Ultrason Sonochem. https://doi.org/10.1016/j.ultsonch.2021.105812 · DOI
  68. Wang F, Kong BL-H, Tang Y-S, Lee H-K, Shaw P-C (2023) Bioassay guided isolation of caffeoylquinic acids from the leaves of Ilex pubescens Hook. et Arn. and investigation of their anti-influenza mechanism. J Ethnopharmacolo. https://doi.org/10.1016/j.jep.2023.116322 · DOI
  69. Wang F, Tang Y-S, Cao F, Shou J-W, Wong C-K, Shaw P-C (2024) 3,4,5-tri-O-caffeoylquinic acid attenuates influenza A virus induced inflammation through Toll-like receptor 3/7 activated signaling pathway. Phytomedicine. https://doi.org/10.1016/j.phymed.2024.155896 · DOI
  70. Wei Z, Yu B, Huang Z, Luo Y, Zheng P, Mao X, Yu J, Luo J, Yan H, Wu A, He J (2024) Potential risk of caffeoylquinic acids, the main polyphenol components in coffee, on the health of piglets. J Agric Food Chem 72(36):20091–20100. https://doi.org/10.1021/acs.jafc.4c04923 · DOI
  71. Wu Q-Z, Zhao D-X, Xiang J, Zhang M, Zhang C-F, Xu X-H (2015) Antitussive, expectorant, and anti-inflammatory activities of four caffeoylquinic acids isolated fromTussilago farfara. Pharm Biol 54(7):1117–1124. https://doi.org/10.3109/13880209.2015.1075048 · DOI
  72. Wu T-Y, Chen C-C, Lin J-Y (2024a) Anti-inflammatory in vitro activities of eleven selected caffeic acid derivatives based on a combination of pro−/anti-inflammatory cytokine secretions and principal component analysis – a comprehensive evaluation. Food Chem. https://doi.org/10.1016/j.foodchem.2024.140201 · DOI
  73. Wu TY, Chen CC, Lin JY (2024b) Anti-inflammatory in vitro activities of eleven selected caffeic acid derivatives based on a combination of pro-/anti-inflammatory cytokine secretions and principal component analysis - a comprehensive evaluation. Food Chem 458:140201. https://doi.org/10.1016/j.foodchem.2024.140201 · DOI
  74. Xiao L, Liang S, Ge L, Wan H, Wu W, Fei J, Wu S, Zhou B, Zeng X (2020) 4,5-di-O-caffeoylquinic acid methyl ester isolated from Lonicera japonica Thunb. targets the Keap1/Nrf2 pathway to attenuate H2O2-induced liver oxidative damage in HepG2 cells. Phytomedicine. https://doi.org/10.1016/j.phymed.2020.153219 · DOI
  75. Xu F, Valappil AK, Zheng S, Zheng B, Yang D, Wang Q (2024) 3,5-DCQA as a major molecule in MeJA-treated dendropanax morbifera adventitious root to promote anti-lung cancer and anti-inflammatory activities. Biomolecules. https://doi.org/10.3390/biom14060705 · DOI
  76. Yang L, Marney L, Magana AA, Choi J, Wright K, McFerrin J, Gray NE, Soumyanath A, Stevens JF, Maier CS (2023) Quantification of caffeoylquinic acids and triterpenes as targeted bioactive compounds of Centella Asiatica in extracts and formulations by liquid chromatography mass spectrometry. J Chromatogr Open. https://doi.org/10.1016/j.jcoa.2023.100091 · DOI
  77. Yoon CH, Jang H-J, Ryu JS, Ko JH, Ahn K-S, Oh S-R, Oh J-H, Chung JH, Oh JY (2023) 1,5-Dicaffeoylquinic acid from Pseudognaphalium affine ameliorates dry eye disease via suppression of inflammation and protection of the ocular surface. Ocul Surf 29:469–479. https://doi.org/10.1016/j.jtos.2023.06.016 · DOI
  78. Yu M-H, Hung T-W, Wang C-C, Wu S-W, Yang T-W, Yang C-Y, Tseng T-H, Wang C-J (2021) Neochlorogenic acid attenuates hepatic lipid accumulation and inflammation via regulating miR-34a in vitro. Int J Mol Sci. https://doi.org/10.3390/ijms222313163 · DOI
  79. Zhang Y, Jiao F, Zeng D, Yu X, Zhou Y, Xue J, Yang W, Guo J (2024a) Synergistic effects of pyrrosia lingua caffeoylquinic acid compounds with levofloxacin against uropathogenic escherichia coli: insights from molecular dynamics simulations, antibiofilm, and antimicrobial assessments. Molecules. https://doi.org/10.3390/molecules29235679 · DOI
  80. Zhang Y, Zhao L, Wang L, Yue R, Zhu H, Zhang W, Sun J, Zhang Z, Ma D (2024b) Chlorogenic acid compounds from sweetpotato (Ipomoea batatas L.) leaves facilitate megakaryocyte differentiation and thrombocytopoiesis via PI3K/AKT pathway. Front Pharmacol. https://doi.org/10.3389/fphar.2024.1414739 · DOI
  81. Zuo G, Kim HY, Guillen Quispe YN, Wang Z, Kim KH, Gonzales Arce PH, Lim SS (2021) Valeriana rigida Ruiz & Pav. Root extract: a new source of caffeoylquinic acids with antioxidant and aldose reductase inhibitory activities. Foods. https://doi.org/10.3390/foods10051079 · DOI

Metadata

Authors
Xiao, Y., Shi, Y., Zhang, J., Xu, N., Liu, C., Zhang, C., Gao, X., Zhou, X., & Qin, K.
Affiliations
Jiangsu Ocean University (CN)
Corresponding author
  • Gao, Xun
  • Zhou, Xunyong
  • Qin, Kunming
ORCID
Venue
Phytochemistry Reviews
Publisher
Springer Science and Business Media LLC
Published
2026-06-23
Volume
25
Issue
7
Pages
5331-5357
ISSN
  • 1568-7767 (ISSN-L)
  • 1572-980X
DOI
10.1007/s11101-026-10280-4
OpenAlex
W7165686509
Cited by
1
References
80
Citations by year
2026: 1
FWCI
3.53
Type
journal article
Language
en
Open access
closed
Licence
Locations
Phytochemistry Reviews (publishedVersion)
Funders
  • National Nature Science Foundation of China (82404860, 82374038)
  • Jiangsu Key Laboratory on Innovation for Marine Medicine and Modern Chinese Medicine (BM2024008)
  • Lianyungang Huaguoshan Talent Program - Double Innovation Talent Project (2024) and Project of Jiangsu Province Agricultural Independent Innovation Fund (CX(24)3059)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Keywords
caffeoylquinic acids, chlorogenic acid, hydroxycinnamic acid esters, regioisomers, acyl migration, matrix effects, biosynthesis, natural occurrence, antioxidant activity, anti-inflammatory activity, antiviral activity, neuroprotection, anticancer activity, plant-based foods, medicinal plants, biological activity

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