Cardiovascular risk in Cushing’s syndrome
Abstract
Chronic cortisol hypersecretion causes central obesity, hypertension, insulin resistance, dyslipidemia, protrombotic state, manifestations which form a metabolic syndrome in all patients with Cushing's syndrome. These associated abnormalities determine an increased cardiovascular risk not only during the active phase of the disease but also long after the "biomedical remission". Clinical management of these patients should be particularly careful in identifying global cardiovascular risk. Considering that remission from hypercortisolism is often difficult to achieve care and control of all cardiovascular risk factors should be one of the primary goals during the follow up of these patients. Extending the indications of the recent consensus on Cushing's syndrome, we suggest to carry out an OGTT to avoid underestimation of diabetes mellitus, an echocardiography and Doppler ultrasonography of the epiaortic vessels in all patients at diagnosis and during follow-up.
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Chronic mild cortisol secretion abnormality may be associated with classic metabolic and cardiovascular complications of hypercortisolism.
“A chronic mild cortisol secretion abnormality may be associated with classic metabolic and cardiovascular complications of hypercortisolism (, -).”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [190]
An oral glucose tolerance test is not always performed in patients with apparently normal fasting glycemia.
“Fasting plasma glucose (FPG) level may not suffice to assess glucose homeostasis in CS because more than one in two patients (%) with endogenous CS and DM have normal FGP levels () and because an oral glucose tolerance test (OGTT) is not always performed in patients with apparently normal fasting glycemia ().”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [190]
Controlling hypercortisolism is the first step toward improving glucose metabolism in endogenous Cushing syndrome, but different treatments may affect diabetes outcome regardless of how well cortisol excess is corrected.
“Controlling hypercortisolism is the first step toward improving glucose metabolism in patients with endogenous CS, but different treatments for hypercortisolism may affect the outcome of diabetes, regardless of how well cortisol excess is corrected (, , , , , , ).”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [190]
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References 18 · Cited by 103
- Authors
- Arnaldi, G., Mancini, T., Polenta, B., & Boscaro, M.
- Affiliations
- Marche Polytechnic University (IT)
- Corresponding author
- Boscaro, Marco
- Venue
- Pituitary
- Published
- 2004-12
- Volume
- 7
- Issue
- 4
- Pages
- 253-256
- ISSN
- 1386-341X (ISSN-L)
- 1573-7403
- OpenAlex
- W2066330033
- Cited by
- 103
- References
- 18
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 3 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 7 · 2016: 2 · 2015: 7 · 2014: 3 · 2013: 5 · 2012: 9
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pituitary (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- Cushing's syndrome, cardiovascular risk, hypercortisolism, metabolic syndrome, abdominal obesity, hypertension, insulin resistance, dyslipidemia, hypercoagulability, diabetes mellitus, oral glucose tolerance test, echocardiography, Doppler ultrasound
- MeSH terms
- Adult, Cardiovascular Diseases, Cushing Syndrome, Echocardiography, Female, Glucose Tolerance Test, Humans, Male, Risk Factors, Ultrasonography, Doppler, Metabolic Syndrome
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