High prevalence of radiological vertebral fractures in women with prolactin-secreting pituitary adenomas
Abstract
Hyperprolactinemia may cause bone loss but data on fractures are scanty. The aim of this study was to evaluate the prevalence of vertebral fractures in women with prolactin (PRL)-secreting adenoma. In this cross-sectional study, 78 women (median age 45.5 years, range: 20-81) with PRL-secreting pituitary adenoma (66 with microadenoma and 12 with macroadenoma) and 156 control subjects, with normal PRL values and with comparable age to patients with hyperprolactinemia, were evaluated for vertebral fractures by a morphometric approach and for bone mineral density (BMD) by a dual-energy X-ray absorptiometry at lumbar spine. Vertebral fractures were shown in 25 patients with PRL-secreting adenoma (32.6%) and in 20 controls (12.8%, P < 0.001). Fractured patients were significantly older (P < 0.001) and had lower BMD T-score (P < 0.001), longer duration of disease (P < 0.001), higher serum PRL (P = 0.004) and lower serum IGF-I (P < 0.001) values as compared to patients who did not fracture. The prevalence of vertebral fractures was significantly (P < 0.001) higher in post-menopausal women with PRL-secreting adenoma as compared to pre-menopausal patients. Fractures occurred more frequently (P = 0.01) in patients with untreated hyperprolactinemia versus patients treated with cabergoline. Logistic regression analysis demonstrated that duration of disease maintained a significant correlation with vertebral fractures (odds ratio 1.16, C.I. 95% 1.02-1.33) even after correction for age, men…
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Higher prevalence of radiological vertebral fractures occurs in women and men with PRL-secreting adenomas compared to controls.
“Mazziotti et al. have shown that higher prevalence of radiological vertebral fractures (VFs) occurs in women and men with PRL-secreting adenomas compared to controls [18, 24].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [24]
Fractures were more frequent in patients with untreated hyperprolactinemia in comparison with patients treated with cabergoline.
“Fractures were more frequent in patients with untreated hyperprolactinemia in comparison with patients treated with cabergoline [18, 24].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [24]
In female patients, prevalence of vertebral fractures was associated with duration of disease independently of hypopituitarism, age, BMD, serum PRL levels, and treatment with dopaminergic drugs.
“In female patients prevalence of VFs was associated with the duration of the disease independently of the effects of hypopituitarism, age, BMD, serum PRL levels, and treatment with dopaminergic drugs [24].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [24]
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References 50 · Cited by 98
- Authors
- Mazziotti, G., Mancini, T., Mormando, M., De Menis, E., Bianchi, A., Doga, M., Porcelli, T., Vescovi, P. P., De Marinis, L., & Giustina, A.
- Affiliations
- University of Brescia (IT)
- Ospedale di Stato della Repubblica di San Marino (SM)
- Azienda Ospedaliera Carlo Poma (IT)
- Corresponding author
- Giustina, Andrea
- Venue
- Pituitary
- Published
- 2011-02-08
- Volume
- 14
- Issue
- 4
- Pages
- 299-306
- ISSN
- 1386-341X (ISSN-L)
- 1573-7403
- OpenAlex
- W2052999878
- Cited by
- 98
- References
- 50
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 13 · 2023: 9 · 2022: 4 · 2021: 11 · 2020: 2 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 5
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pituitary (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- prolactinoma, hyperprolactinemia, vertebral fractures, bone loss, bone mineral density, insulin-like growth factor I, cabergoline, postmenopausal women, disease duration, pituitary adenoma
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Lumbar Vertebrae, Middle Aged, Pituitary Neoplasms, Prolactinoma, Absorptiometry, Photon, Bone Density, Prevalence, Spinal Fractures, Young Adult
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