Perspectives of cyanobacterial cell factories
Open accessAbstract
Cyanobacteria are prokaryotic photosynthetic microorganisms that can generate, in addition to biomass, useful chemicals and proteins/enzymes, essentially from sunlight, carbon dioxide, and water. Selected aspects of cyanobacterial production (isoprenoids and high-value proteins) and scale-up methods suitable for product generation and downstream processing are addressed in this review. The work focuses on the challenge and promise of specialty chemicals and proteins production, with isoprenoid products and biopharma proteins as study cases, and the challenges encountered in the expression of recombinant proteins/enzymes, which underline the essence of synthetic biology with these microorganisms. Progress and the current state-of-the-art in these targeted topics are emphasized.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These developments have enabled the efficient introduction and expression of heterologous metabolic pathways within cyanobacterial hosts, supporting the biosynthesis of compounds that are not naturally produced by these organisms.
“These developments have enabled the efficient introduction and expression of heterologous metabolic pathways within cyanobacterial hosts, supporting the biosynthesis of compounds that are not naturally produced by these organisms [10,18].”
From Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression (2026) · cites this paper as [18]
The Preface (page unavailable) describes more efficient genetic engineering and reports that engineered cyanobacteria produce a range of compounds, including products of heterologous pathways. But the Biopharmaceutical and other recombinant protein synthesis section (page unavailable) says heterologous proteins are often poorly tolerated and that achieving high expression remains a barrier. The claim overstates how efficiently such pathways can generally be expressed. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 108 · Cited by 31
Research works printed but not linked: 1
- Sethia P, Ahuja M, Rangaswamy V (2019) Metabolic engineering of microorganisms to produce isoprene. J Microbial & Biochem Technology 11(4):419. 10.4172/1948-5948.1000419 · DOI
- Authors
- Melis, A., Hidalgo Martinez, D. A., & Betterle, N.
- Affiliations
- University of California, Berkeley (US)
- University of Verona (IT)
- Corresponding author
- Melis, Anastasios
- Venue
- Photosynthesis Research
- Published
- 2023-11-15
- Volume
- 162
- Issue
- 2-3
- Pages
- 459-471
- ISSN
- 0166-8595 (ISSN-L)
- 1573-5079
- PMC
- PMC11615099
- OpenAlex
- W4388699100
- Cited by
- 31
- References
- 108
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 6
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Photosynthesis Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- cyanobacteria, terpenoids, biopharmaceutical proteins, recombinant protein expression, synthetic biology, scale-up, downstream processing, photosynthetic production
- MeSH terms
- Cyanobacteria, Photosynthesis, Recombinant Proteins, Terpenes, Synthetic Biology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
