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Validity of EQ-5D-5L in stroke

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Golicki, Dominik, Niewada, Maciej, Buczek, Julia, Karlińska, Anna, Kobayashi, Adam, Janssen, M. F., Pickard, A. Simon·2015·Quality of Life Research

DOI 10.1007/s11136-014-0834-1PMC PMC4366565

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Abstract

PURPOSE: To assess EQ-5D-5L (5L) validity in patients with acute stroke, in comparison with EQ-5D-3L (3L). METHODS: Cross-sectional study of 408 patients during index hospitalization. We compared 5L and 3L in terms of feasibility, frequency of unique health states, ceiling effect and discriminatory power (informativity). We assessed construct validity in terms of known-groups validity and convergent validity of 5L dimensions with other stroke outcome measures. RESULTS: The overall proportion of patients with acute stroke reporting 'no problems' with 3L-6.1 % was further reduced to 5.6 % with 5L (relative reduction of 8.2 %). The highest improvement in relative discriminatory power, when moving from 3L to 5L, was noticed in pain/discomfort and anxiety/depression dimensions (Shannon Evenness Index 0.91 for both 5L dimensions; relative increase 34.4 and 29.1 %, respectively). Known-groups validity tests confirmed prior hypotheses: Health state utilities were lower in following subpopulations-females, patients with high modified Rankin Scale (mRS) score, low Barthel Index (BI) or VAS score, patients with subarachnoid hemorrhage or intracerebral hemorrhage, and when proxy respondent was used. Convergence of EQ-5D-5L dimensions with mRS, BI and EQ VAS was improved or at least the same as for 3L dimensions. CONCLUSIONS: Results support the validity of the EQ-5D-5L descriptive system as a generic health outcome measure in patients with acute stroke, demonstrating some psychometric advantages in comparison with EQ-5D-3L.

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Authors: Golicki, D., Niewada, M., Buczek, J., Karlińska, A., Kobayashi, A., Janssen, M. F., & Pickard, A. S.
Affiliations: Medical University of Warsaw (PL)
Institute of Psychiatry and Neurology (PL)
Erasmus MC (NL)
University of Illinois Chicago (US)
Corresponding author: Golicki, Dominik
ORCID: Golicki, Dominik
Niewada, Maciej
Kobayashi, Adam
Janssen, M. F.
Pickard, A. Simon
Venue: Quality of Life Research
Publisher: Springer Science and Business Media LLC
Published: 2014-10-28
Volume: 24
Issue: 4
Pages: 845-850
ISSN: 0962-9343 (ISSN-L)
1573-2649
DOI: 10.1007/s11136-014-0834-1
PMC: PMC4366565
OpenAlex: W2021768440
Cited by: 254
References: 25
Citations by year: 2026: 20 · 2025: 18 · 2024: 31 · 2023: 25 · 2022: 24 · 2021: 31 · 2020: 40 · 2019: 16 · 2018: 23 · 2017: 6 · 2016: 14 · 2015: 5
FWCI: 20.72
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: Quality of Life Research (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (acceptedVersion, other-oa)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Topics: Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Health Sciences › Nursing › Research and Theory › Health Education and Validation
Social Sciences › Sociology and Political Science › Delphi Technique in Research
Keywords: EQ-5D-5L, EQ-5D-3L, acute stroke, health-related quality of life, construct validity, known-groups validity, convergent validity, ceiling effect, discriminatory power, proxy respondents, subarachnoid hemorrhage, intracerebral hemorrhage, modified Rankin Scale, Barthel Index
MeSH terms: Adult, Aged, Aged, 80 and over, Anxiety, Cerebral Infarction, Cross-Sectional Studies, Depression, Female, Health Status, Hospitalization, Humans, Male, Middle Aged, Orthotic Devices, Pain, Pain Measurement, Psychometrics, Quality of Life, Surveys and Questionnaires, Subarachnoid Hemorrhage, Reproducibility of Results, Outcome Assessment, Health Care, Young Adult, Self Report

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