Impact of home-based aerobic exercise on the physical capacity of overweight patients with chronic kidney disease
Abstract
Background Home-based exercise has been shown to provide benefits in terms of physical capacity in the general population, but has been scarcely investigated in patients with chronic kidney disease (CKD). Aims To evaluate the impact of a home-based aerobic training on the cardiopulmonary and functional capacities of overweight non-dialysis-dependent patients with CKD (NDD-CKD). Methods Twenty-nine sedentary patients (55.1 ± 11.6 years, BMI = 31.2 ± 6.1 kg/m(2), eGFR = 26.9 ± 17.4 mL/min/1.73 m(2)) were randomly assigned to a home-based exercise group (n = 14) or to a control group (n = 15) that remained without performing exercise. Aerobic training was performed three times per week for 12 weeks. A cardiopulmonary exercise test, functional capacity and clinical parameters were evaluated. Results A significant increase, ranging from 8.3 to 17 %, was observed in the cardiopulmonary capacity parameters, such as maximal ventilation (p = 0.005), VO2peak (p = 0.049), ventilatory threshold (p = 0.040) and respiratory compensation point (p Conclusion The home-based aerobic exercise program was feasible, safe and effective for the improvement in the cardiopulmonary and functional capacities of overweight NDD-CKD patients.
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Risk for detection bias was unclear in 4 RCTs and high in the Kiuchi study only.
“Risk for detection bias was unclear in 4 RCTs [7, 13, 20, 21], and was scored as high in Kiuchi study only [15].”
From Exercise therapy improves eGFR, and reduces blood pressure and BMI in non-dialysis CKD patients: evidence from a meta-analysis (2019) · cites this paper as [7]
High risk of performance bias was granted to more than 75% of the included studies.
“high risk of performance bias was granted to more than 75% of the studies [7, 9, 10, 13, 15–18, 20, 21].”
From Exercise therapy improves eGFR, and reduces blood pressure and BMI in non-dialysis CKD patients: evidence from a meta-analysis (2019) · cites this paper as [7]
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References 52 · Cited by 81
- Authors
- Aoike, D. T., Baria, F., Kamimura, M. A., Ammirati, A., de Mello, M. T., & Cuppari, L.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Venue
- International Urology and Nephrology
- Published
- 2014-12-11
- Volume
- 47
- Issue
- 2
- Pages
- 359-367
- ISSN
- 0301-1623 (ISSN-L)
- 1573-2584
- OpenAlex
- W2120357024
- Cited by
- 81
- References
- 52
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 11 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 3 · 2017: 6 · 2016: 4
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Urology and Nephrology (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- chronic kidney disease, overweight, physical capacity, cardiopulmonary exercise capacity, functional capacity, blood pressure reduction, renal function, sedentary patients
- MeSH terms
- Aged, Blood Pressure, Exercise Test, Exercise Therapy, Female, Glomerular Filtration Rate, Heart Rate, Humans, Male, Middle Aged, Oxygen Consumption, Physical Fitness, Pulmonary Ventilation, Exercise, Exercise Tolerance, Overweight, Renal Insufficiency, Chronic, Sedentary Behavior
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