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Cited by 27Antifungal resistance and susceptibilitySirtuins and Resveratrol in MedicineEssential Oils and Antimicrobial Activity

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Resveratrol lacks antifungal activity against Candida albicans

Open access
Collado-González, Mar, Guirao-Abad, José P., Sánchez-Fresneda, Ruth, Belchí-Navarro, Sarai, Argüelles, Juan-Carlos·2012·World Journal of Microbiology and Biotechnology
DOI 10.1007/s11274-012-1042-1
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Abstract

The putative candicidal activity of resveratrol is currently a matter of controversy. Here, the antifungal activity as well as the antioxidant response of resveratrol against Candida albicans, have been tested in a set of strains with a well-established genetic background At the doses usually employed in antifungal tests (10-40 μg/ml), resveratrol has no effect on the exponential growth of the C. albicans CAI.4 strain, a tenfold increase (400 μg/ml) was required in order to record a certain degree of cell killing, which was negligible in comparison with the strong antifungal effect caused by the addition of amphotericin B (5 μg/ml). An identical pattern was recorded in the prototrophic strains of C. albicans SC5314 and RM-100, whereas the oxidative sensitive trehalose-deficient mutant (tps1/tps1 strain) was totally refractory to the presence of resveratrol. In turn, the serum-induced yeast-to-hypha transition remained unaffected upon addition of different concentrations of resveratrol. Determination of endogenous trehalose and catalase activity, two antioxidant markers in C. albicans; revealed no significant changes in their basal contents induced by resveratrol. Collectively, our results seem to dismiss a main antifungal role as well as the therapeutic application of resveratrol against the infections caused by C. albicans.

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Citations

Cites

  • Fungicidal Effect of Resveratrol on Human Infectious Fungi

    Jung, H. J., Hwang, I. A., Sung, W. S., Kang, H., Kang, B. S., Seu, Y. B., & Lee, D. G. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02977758 · Cited by 107 · cited 1×

    “It has also been proposed a strong antifungal action of resveratrol against candidal infections (Jung et al. 2005, 2007), a process that would also encompasses the inhibition of the yeast-to-hypha dimorphic transition (OkamotoShibayama et al. 2010).”

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Research works printed but not linked: 26

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Cited by

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Metadata

Authors
Collado-González, M., Guirao-Abad, J. P., Sánchez-Fresneda, R., Belchí-Navarro, S., & Argüelles, J.-C.
Affiliations
Universidad de Murcia (ES)
Corresponding author
Argüelles, Juan-Carlos
ORCID
Venue
World Journal of Microbiology and Biotechnology
Publisher
Springer Science and Business Media LLC
Published
2012-03-30
Volume
28
Issue
6
Pages
2441-2446
ISSN
  • 0959-3993 (ISSN-L)
  • 1573-0972
DOI
10.1007/s11274-012-1042-1
OpenAlex
W2038507995
Cited by
27
References
1
Citations by year
2026: 1 · 2025: 5 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2014: 3
FWCI
0.66
Type
journal article
Language
en
Open access
Licence
  • cc-by-nc-nd
  • www.springer.com/tdm (tdm)
Locations
  • World Journal of Microbiology and Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • Hispana (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Keywords
resveratrol, Candida albicans, antifungal activity, yeast-to-hypha transition, catalase activity, antioxidant response, amphotericin B, antifungal resistance
MeSH terms
Resveratrol, Antifungal Agents, Candida albicans, Stilbenes

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CoChat. (2026). Citation check: Resveratrol lacks antifungal activity against Candida albicans. https://app.cochat.ai/papers/10.1007/s11274-012-1042-1
The paper
Collado-González, M., Guirao-Abad, J. P., Sánchez-Fresneda, R., Belchí-Navarro, S., & Argüelles, J.-C. (2012). Resveratrol lacks antifungal activity against Candida albicans. World Journal of Microbiology and Biotechnology. https://doi.org/10.1007/s11274-012-1042-1

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