Anti-infective potential of plant-derived quorum sensing inhibitors against multi-drug resistant human and aquatic bacterial pathogens
Abstract
The present study intended to decipher the anti-infective potential of bioactive phytocompounds, such as rosmarinic acid, morin, naringin, chlorogenic acid, and mangiferin, against aquatic and human bacterial pathogens using Artemia spp. nauplii and Caenorhabditis elegans as animal models, respectively. Initially, the test compounds were screened against the QS traits in Vibrio spp., such as bioluminescence production and biofilm formation. The test compounds effectively inhibited the bioluminescence in V. harveyi. Further, the confocal laser scanning microscopic analysis revealed that these natural compounds could efficiently reduce the clumping morphology, a characteristic biofilm formation in Vibrio spp., without inhibiting bacterial growth. The results of in vivo analysis showed a significant increase in the survival of Artemia spp. nauplii infected with Vibrio spp. upon exposure to these compounds. Moreover, the compounds used in this study were already proven and reported for their quorum sensing inhibitory efficacy against Pseudomonas aeruginosa. Hence, the anti-infective efficacy of these compounds against P. aeruginosa (PAO1) and its clinical isolates (AS1 and AS2) was studied using C. elegans as a live animal model system. The results of time-killing assay deciphered that rosmarinic acid and naringin are being the most effective ones in rescuing the animals from P. aeruginosa infection followed by morin, mangiferin, and chlorogenic acid. Further, the toxicity result…
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In Caenorhabditis elegans infected with P. aeruginosa, MGF compounds regulate quorum sensing pathways and reduce bacterial virulence in dauer larvae and adult stages.
“In Caenorhabditis elegans models infected with P. aeruginosa, MGF compounds regulate quorum sensing pathways and reduce bacterial virulence in both dauer larvae and adult stages, further supporting their anti-infective potential (156).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [156]
Cites
Brackman, G., Defoirdt, T., Miyamoto, C., Bossier, P., Van Calenbergh, S., Nelis, H., & Coenye, T. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-149 · Cited by 317 · see citing works
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Mangiferin in human disease: Multifaceted mechanisms and applications (Review)
Dai, Y., Huang, Q., Tan, M., Wang, Z., Jiang, C., Liu, Z., Zhang, S., & Song, S. (2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2026.5736 · Cited by 3 · see citing works
“In Caenorhabditis elegans models infected with P. aeruginosa , MGF compounds regulate quorum sensing pathways and reduce bacterial virulence in both dauer larvae and adult stages, further supporting their anti‑infective potential (156).”
- Authors
- Angusamy, A., Balasubramanian, V., Arunmurugan, B., Arunachalam, K., Issac Abraham, S. V. P., Murugesan, S., Krishnasamy, B., Sundaram, J., & Arumugam, V. R.
- Affiliations
- Alagappa University (IN)
- ORCID
- Arumugam, Veera Ravi
- Venue
- World Journal of Microbiology and Biotechnology
- Published
- 2023-04-06
- Volume
- 39
- Issue
- 6
- Pages
- 147-147
- ISSN
- 0959-3993 (ISSN-L)
- 1573-0972
- OpenAlex
- W4362657240
- Cited by
- 10
- References
- 1
- Citations by year
- 2026: 5 · 2025: 3 · 2023: 2
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- World Journal of Microbiology and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research, India (CSIR SRF No. 9/688 (0014)/2011)
- University Grants Commission (Grant No: F.4-2/2006(BSR)/BL/18-19/0298)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- quorum sensing inhibitors, phytochemicals, multidrug-resistant bacteria, Vibrio harveyi, Pseudomonas aeruginosa, rosmarinic acid, morin, naringin, chlorogenic acid, mangiferin, biofilm formation, bioluminescence, human pathogenic bacteria, Artemia nauplii, Caenorhabditis elegans
- MeSH terms
- Rosmarinic Acid, Animals, Anti-Infective Agents, Anti-Bacterial Agents, Chlorogenic Acid, Humans, Pseudomonas aeruginosa, Vibrio, Caenorhabditis elegans, Biofilms, Virulence Factors, Quorum Sensing
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