Cited by 70Moringa oleifera research and applicationsDrug-Induced Hepatotoxicity and ProtectionNigella sativa pharmacological applications

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Protective effect of Moringa oleifera leaves ethanolic extract against thioacetamide-induced hepatotoxicity in rats via modulation of cellular antioxidant, apoptotic and inflammatory markers

Mousa, Ahmed Abdelmoniem, El-Gansh, Hala Ali Ibrahim, Eldaim, Mabrouk Attia Abd, Mohamed, Mostafa Abd El-Gaber, Morsi, Azza Hassan, El Sabagh, Hesham Saad·2019·Environmental Science and Pollution Research

DOI 10.1007/s11356-019-06368-4

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Abstract

The current study was conducted to evaluate the ameliorative and protective potentials of Moringea oleifera leaves ethanolic extract (MOLE) against thioacetamide (TAA) toxicity. A total of 58 male albino rats were randomly assigned into six experimental groups. G1, rats received distilled water. G2, rats were injected with a single dose of TAA (200 mg/kg BW) i.p. G3, rats were given MOLE (300 mg/kg BW) orally for 26 days. G4, rats were injected TAA as in G2 and treated with MOLE as G3. G5, rats were kept for 26 days without treatment then on day 27 injected with TAA as in G2. G6, rats were given MOLE for 26 days then on day 27 injected with TAA. Phytochemical analysis of MOLE indicated the presence of kaempferol, kaempferol malonylglucoside, kaempferol hexoside, kaempferol -3-O-glucoside, kaempferol-3-O-acetyl-glucoside, cyanidin -3-O-hexoside, ellagic acid, quercetin, quercetin-3-O-glucoside, and apigenin glucoside. Intoxication of rats with TAA significantly elevated activities of serum AST, ALT, and ALP; concentrations of malondialdehyde, nitric oxide, and hepatic tissue protein expression of caspase 3 and COX2 with alteration of the histological structures of hepatic tissues, while it decreased serum levels of total protein, albumin, and hepatic tissue contents of reduced glutathione. Also, TAA intoxication resulted in 62.5% mortality in rats of G5. Treatment of TAA intoxicated rats (G4) with MOLE ameliorated the toxic effects of TAA on hepatic tissue structure and function. It decreased serum activities of AST, ALT, and ALP; enhanced hepatic GSH concentration; reduced pathological alterations and lipid peroxidation; and downregulated caspase 3 and COX2 proteins expression in hepatic tissue. In addition, MOLE protected rats of G6 from TAA-induced hepatic tissues injury and dysfunction, and increased survival rate of rats. In conclusion, MOLE had both ameliorating and protecting potentials against TAA-induced rats liver damage through regulation of antioxidant, anti-apoptotic, and inflammatory biomarkers. Graphical abstract.

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Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity
Hernandez-Fuentes, G. A., Delgado-Enciso, O. G., Larios-Cedeño, E. G., Sánchez-Galindo, J. M., Ceballos-Magaña, S. G., Pineda-Urbina, K., Alcalá-Pérez, M. A., Magaña-Vergara, N. E., Delgado-Enciso, J., Díaz-Llerenas, U., et al. (2024) · Life · doi:10.3390/life14121702 · Cited by 15

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Authors: Mousa, A. A., El-Gansh, H. A. I., Eldaim, M. A. A., Mohamed, M. A. E.-G., Morsi, A. H., & El Sabagh, H. S.
Affiliations: University of Sadat City (EG)
Menoufia University (EG)
Cairo University (EG)
Corresponding author: Eldaim, Mabrouk Attia Abd
ORCID: Eldaim, Mabrouk Attia Abd
Mohamed, Mostafa Abd El-Gaber
Venue: Environmental Science and Pollution Research
Publisher: Springer Science and Business Media LLC
Published: 2019-10-15
Volume: 26
Issue: 31
Pages: 32488-32504
ISSN: 0944-1344 (ISSN-L)
1614-7499
DOI: 10.1007/s11356-019-06368-4
OpenAlex: W2980361925
Cited by: 70
References: 86
Citations by year: 2026: 8 · 2025: 10 · 2024: 10 · 2023: 12 · 2022: 12 · 2021: 10 · 2020: 8
FWCI: 5.53
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Environmental Science and Pollution Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Moringa oleifera research and applications
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Health Sciences › Medicine › Complementary and alternative medicine › Nigella sativa pharmacological applications
Keywords: Moringa oleifera, thioacetamide, hepatotoxicity, hepatoprotection, antioxidant defense, apoptosis, inflammation, caspase-3, cyclooxygenase-2, lipid peroxidation, oxidative stress, glutathione, kaempferol, quercetin, phytochemicals, liver enzymes, survival rate
MeSH terms: Animals, Antioxidants, Glucosides, Glutathione, Liver, Male, Malondialdehyde, Plant Extracts, Quercetin, Thioacetamide, Lipid Peroxidation, Biomarkers, Rats, Wistar, Plant Leaves, Protective Agents, Moringa oleifera, Rats, Chemical and Drug Induced Liver Injury

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Protective effect of Moringa oleifera leaves ethanolic extract against thioacetamide-induced hepatotoxicity in rats via modulation of cellular antioxidant, apoptotic and inflammatory markers

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