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Integrated toxicity assessment of DEHP and DBP toward aquatic ecosystem based on multiple trophic model assays
Abstract
To comprehensively understand the toxic risks of phthalates to aquatic ecosystems, we examined the acute toxicity of di-(2-ethylhexyl) phthalate (DEHP) and di-butyl phthalate (DBP) on multiple trophic models, including algae (Chlorella vulgaris), Daphnia magna and fish (Danio rerio, Pseudorasbora parva). Thus, a 15-day zebrafish exposure was conducted to trace the dynamic changes of phthalate-induced toxic effects. Among the four species, D. magna exhibited the strongest sensitivity to both DEHP and DBP, followed by D. rerio and P. parva. C. vulgaris exhibited the lowest sensitivity to phthalates. The sub-chronic zebrafish assay demonstrated that 1000 μg/L DBP induced significant mortality at 15 days post-exposure (dpe), and DEHP exhibited no lethality at the tested concentrations (10-5000 μg/L). Zebrafish hepatic SOD activity and sod transcription levels were inhibited by DBP from 3 dpe, which was accompanied by increased malondialdehyde level, while zebrafish exposed to DEHP exhibited less oxidative damage. Both DEHP and DBP induced time-dependent alterations on Ache activity in zebrafish brains, thus indicating the potential neurotoxicity toward aquatic organisms. Additionally, 1000 μg/L and higher concentration of DBP caused hepatic DNA damage in zebrafish from 7 dpe. These results provide a better understanding of the health risks of phthalate to water environment.
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“Yuan et al. (2022) established that intermediate trophic level organisms, such as the aquatic microcrustacean Daphnia magna , exhibit the highest sensitivity to phthalates, including DEHP, following 15-days exposure, in comparison to species at lower and higher trophic levels.”
From Trophic transfer of polyester microfibres across a multi-level marine food web. (2025) · cites this paper as Yuan et al., 2022
In the citing paper
“The authors surmised that prolonged exposure to phthalates may disrupt aquatic food chain dynamics, potentially leading to an overabundance of primary producers such as algae.”
From Trophic transfer of polyester microfibres across a multi-level marine food web. (2025) · cites this paper as Yuan et al., 2022
Citations
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References 70 · Cited by 29
Research works printed but not linked: 2
- Ping LW, Li XX, Zhang C, Song PP, Wang JH, Zhu LS, Wang J (2018) Oxidative stress and DNA damage induced by DEP exposure in earthworms. Huan Jing Ke Xue 39(10):4825–4833
- Sha Y, Xia X, Xiao X (2006) Distribution characters of phthalic acid ester in the waters middle and lower reaches of the Yellow River. China Environ Sci 26(1):120–124
Metadata
- Authors
- Yuan, L., Liu, J., Huang, Y., Shen, G., Pang, S., Wang, C., Li, Y., & Mu, X.
- Affiliations
- Chinese Academy of Fishery Sciences (CN)
- China Agricultural University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Corresponding author
- Mu, Xiyan
- Venue
- Environmental Science and Pollution Research
- Published
- 2022-07-09
- Volume
- 29
- Issue
- 58
- Pages
- 87402-87412
- ISSN
- 0944-1344 (ISSN-L)
- 1614-7499
- OpenAlex
- W4284974290
- Cited by
- 29
- References
- 70
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 7 · 2023: 3
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Science and Pollution Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences (NO. 2017HY-ZD0201, 2019ZY07, 2020TD11)
- the Young Elite Scientists Sponsorship Program by CAST (2018QNRC001)
- the Central Public-interest Scientific Institution Basal Research Fund (No. Y2022QC18)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- DEHP, dibutyl phthalate, phthalates, aquatic toxicity, Daphnia magna, zebrafish, Pseudorasbora parva, Chlorella vulgaris, subchronic exposure, oxidative stress, superoxide dismutase, malondialdehyde, acetylcholinesterase, neurotoxicity, hepatic DNA damage, aquatic ecosystem risk
- MeSH terms
- Animals, Dibutyl Phthalate, Diethylhexyl Phthalate, Phthalic Acids, Superoxide Dismutase, Zebrafish, Ecosystem, Chlorella vulgaris
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- CoChat. (2026). Citation check: Integrated toxicity assessment of DEHP and DBP toward aquatic ecosystem based on multiple trophic model assays. https://app.cochat.ai/papers/10.1007/s11356-022-21863-x
- The paper
- Yuan, L., Liu, J., Huang, Y., Shen, G., Pang, S., Wang, C., Li, Y., & Mu, X. (2022). Integrated toxicity assessment of DEHP and DBP toward aquatic ecosystem based on multiple trophic model assays. Environmental Science and Pollution Research. https://doi.org/10.1007/s11356-022-21863-x
