The differential impact of air pollutants on acute urticaria and chronic urticaria: a time series analysis
Abstract
Several studies have revealed a relationship between short-term exposure to air pollution and the exacerbation of certain skin conditions. This study was developed to expand on these findings by exploring the potential association between exposure to air pollutants including particulate matter, sulfur dioxide, and ozone and the incidence of acute and chronic urticaria in Shenyang, China, from 2016 to 2018. Exposure-response relationships between daily mean concentrations of these airborne pollutants and visits to outpatient dermatological clinics for acute urticaria and chronic urticaria were evaluated via a time series analysis approach using a generalized additive model. This analysis revealed that a 10 μg/m 3 increase in daily mean O 3 _8h concentrations was associated with a 0.36% (95% CI, 0.31-0.41%), 0.35% (95% CI, 0.30-0.40%), and 0.34% (95% CI, 0.29-0.39%) increase in the number of outpatient visits for acute urticaria on that day (lag0), lagging day 1 (lag1), and lagging day 2 (lag2), respectively. O3 levels also had a similar but weaker effect on the frequency of patients seeking outpatient care for chronic urticaria. These analyses also revealed that estimated 0.47% (95% CI, 0.41-0.52%) and 0.46% (95% CI, 0.40-0.51%) increases in dermatological outpatient acute urticaria visits were observed for every 10μg/m3 rise in O3_8h concentrations on cumulative lagging days (lag01 and lag02). Increases in particulate matter (PM 2.5, PM 10) levels had a similar cumulative effect on patients with chronic urticaria. In summary, these results suggest that short-term O 3, PM 2.5, and PM 10 exposure can increase the risk of acute urticaria and chronic urticaria.
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Both short- and long-term studies reported strong associations between urticaria and particulate pollutants such as PM2.5 and PM10.
“while both short- and long-term studies reported strong associations between urticaria and particulate pollutants such as PM2.5 and PM10 [75, 76].”
From Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence (2026) · cites this paper as [75]
The time-series results (p. 5) report significant associations between short-term PM2.5 and PM10 exposure and chronic-urticaria outpatient visits. The paper analyzes daily exposure and lagged effects, not long-term exposure; it also describes the PM10 effect as weaker, so it does not support calling both associations strong. (LLM, conf=0.88)
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References 33 · Cited by 13
Research works printed but not linked: 3
- [15]15. Lefebvre M-A, Pham D-M, Boussouira B, Qiu H, Ye C, Long X, Chen R, Gu W, Laurent A, Nguyen Q-L (2016): Consequences of urban pollution upon skin status. A controlled study in Shanghai area. International Journal of Cosmetic Science 38, 217-223
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- [30]30. Yunquan, Zhang, Cunlu, Li, Renjie, Feng, Yaohui, Zhu, Kai, Wu (2016): The Short-Term Effect of Ambient Temperature on Mortality in Wuhan, China: A Time-Series Study Using a Distributed Lag Non-Linear Model. International journal of environmental research and public health
- Authors
- Li, J., Song, G., Mu, Z., Lan, X., Yang, F., Li, L., & Han, X.
- Affiliations
- Sheng Jing Hospital (CN)
- Corresponding author
- Han, Xiuping
- Venue
- Environmental Science and Pollution Research
- Published
- 2022-09-26
- Volume
- 30
- Issue
- 6
- Pages
- 14656-14662
- ISSN
- 0944-1344 (ISSN-L)
- 1614-7499
- OpenAlex
- W4297237907
- Cited by
- 13
- References
- 33
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Environmental Science and Pollution Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Rheumatology › Urticaria and Related Conditions
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- acute urticaria, chronic urticaria, air pollution, ozone, particulate matter, PM2.5, PM10, sulfur dioxide, exposure-response relationship, Shenyang
- MeSH terms
- Chronic Urticaria, Air Pollutants, Air Pollution, China, Environmental Exposure, Humans, Nitrogen Dioxide, Ozone, Time Factors, Urticaria, Particulate Matter
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