How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?
Open accessAbstract
Cytomegalovirus (CMV) is an important pathogen for both clinical and population settings. There is a growing body of research implicating CMV in multiple health outcomes across the life course. At the same time, there is mounting evidence that individuals living in poverty are more likely to be exposed to CMV and more likely to experience many of the chronic conditions for which CMV has been implicated. Further research on the causal role of CMV for health and well-being is needed. However, the strong evidence implicating CMV in type 2 diabetes, autoimmunity, cancer, cardiovascular disease, vaccination, and age-related alterations in immune function warrants clinical and public health action. This imperative is even higher among individuals living in socioeconomically disadvantaged settings and those exposed to high levels of chronic psychosocial stress.
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Some studies have found that human CMV infection in older individuals is associated with increased cardiovascular and all-cause mortality, negative immune risk profile, inflammageing, and lower antibody responses to influenza.
“Some studies have found that human CMV infection in older individuals is associated with increased cardiovascular and all-cause mortality, negative immune risk profile, inflammageing, and lower antibody responses to influenza125–129.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [129]
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References 103 · Cited by 73
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- lu2220oa · DOI
- Authors
- Aiello, A. E., Chiu, Y.-L., & Frasca, D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Far Eastern Memorial Hospital (TW)
- University of Miami (US)
- Corresponding author
- Frasca, Daniela
- Venue
- GeroScience
- Published
- 2017-06
- Volume
- 39
- Issue
- 3
- Pages
- 261-271
- ISSN
- 2152-4041 (ISSN-L)
- 2509-2715
- 2509-2723
- PMC
- PMC5505887
- OpenAlex
- W2626113915
- Cited by
- 73
- References
- 103
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 11 · 2018: 8 · 2017: 3
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- GeroScience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (AG32576, AI096446, HD050924, DA022720, MD002249, AG040115, DK087864)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- cytomegalovirus, aging, vaccine response, type 2 diabetes, autoimmunity, cancer, cardiovascular disease, age-related immune decline, poverty, socioeconomic deprivation, psychosocial stress, chronic disease, life course
- MeSH terms
- Aging, Chronic Disease, Congresses as Topic, Cytomegalovirus Infections, Cytomegalovirus, Humans, Poverty, Risk Factors, United States, Vaccination, Evidence-Based Medicine, Cytomegalovirus Vaccines
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