Functional study of hyperpolarization activated channel (I h ) in Drosophila behavior
Open accessAbstract
Hyperpolarization-activated, cyclic nucleotide-gated and cation-nonselective ion channels (I ( h ) channels, or HCN channels) are known to play important roles in mammals. Their physiological functions in invertebrate remain largely unclear. Here, we report our studies with I ( h ) channel in Drosophila melanogaster. Drosophila Ih channel mutants are found with several defects by behavioral analyses. Their lifespan is reduced, and their chemical sensitivity is shifted. In addition, their length of sleep at light-dark condition is mildly reduced. We generated transgenic flies of I ( h ) promoter-driven Gal4 and examined its expression pattern in both larvae and adult flies. Our results suggest that I ( h ) channel may play diverse roles in Drosophila and provide a basis to further expand our understanding of Drosophila Ih channel function in vivo.
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Drosophila with HCN channel mutations sleep less than sibling controls.
“this genotype leads both male and female mutant flies to sleep less than their sibling controls [63].”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [63]
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References 17 · Cited by 22
- Authors
- Chen, Z., & Wang, Z.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Wang, ZuoRen
- ORCID
- Wang, ZuoRen
- Venue
- Science China Life Sciences
- Published
- 2012-01
- Volume
- 55
- Issue
- 1
- Pages
- 2-7
- ISSN
- 1674-7305 (ISSN-L)
- 1869-1889
- OpenAlex
- W2029767352
- Cited by
- 22
- References
- 17
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 10 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Science China Life Sciences (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- hyperpolarization-activated channels, HCN channels, Drosophila melanogaster, lifespan, chemosensitivity, sleep behavior, light-dark cycle, invertebrate physiology
- MeSH terms
- Animals, Behavior, Animal, Drosophila melanogaster, Neurons, Sleep, Taste, Wings, Animal, Potassium Channels, Drosophila Proteins, Animals, Genetically Modified, Cyclic Nucleotide-Gated Cation Channels, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
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