Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice
Abstract
We report herein a study of aging using in vitro and in vivo models. Glial fibrillary acidic protein and ferritin expression levels increased, and the levels of glutamate transporter 1 and transferrin receptor 1 decreased in aging mouse spinal cord and its astrocytes. Mitochondrial transmembrane potential in astrocytes decreased after 60 d of culture. Given the relationship between aging and loss of antioxidant tolerance capacity, we examined the expression of heme oxygenase 1 (HO1) and NAD(P)H/quinone oxidoreductase 1 (NQO1) in the old mouse astrocytes and spinal cord. Indeed, both antioxidant enzymes decreased there. Total nuclear factor E2-related factor 2, which governs basal and inducible expression of HO1 and NQO1, decreased significantly. Significantly, epigallocatechin gallate restored the Nrf2 activity.
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Nrf2 levels decrease with aging.
“Studies have found an inverse correlation between aging and Nrf2 expression, both in mouse tissues and in vitro during replicative senescence”
From Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism (2017) · cites this paper as Duan et al., 2009
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References 23 · Cited by 75
- Authors
- Duan, W., Zhang, R., Guo, Y., Jiang, Y., Huang, Y., Jiang, H., & Li, C.
- Affiliations
- Second Hospital of Hebei Medical University (CN)
- Corresponding author
- Li, Chunyan
- Venue
- In Vitro Cellular & Developmental Biology - Animal
- Published
- 2009-05-19
- Volume
- 45
- Issue
- 7
- Pages
- 388-397
- ISSN
- 1071-2690 (ISSN-L)
- 1543-706X
- OpenAlex
- W2019058725
- Cited by
- 75
- References
- 23
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 6 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- In Vitro Cellular & Developmental Biology - Animal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Keywords
- Nrf2, aging, spinal cord, astrocytes, heme oxygenase-1, NQO1, antioxidant enzymes, mitochondrial membrane potential, GLT-1, transferrin receptor 1, glial fibrillary acidic protein, ferritin, epigallocatechin gallate, oxidative stress
- MeSH terms
- Aging, Animals, Astrocytes, Catechin, Cells, Cultured, Ferritins, Glial Fibrillary Acidic Protein, NADPH Dehydrogenase, Receptors, Transferrin, Spinal Cord, Time Factors, NAD(P)H Dehydrogenase (Quinone), Neuroprotective Agents, Models, Animal, Excitatory Amino Acid Transporter 2, NF-E2-Related Factor 2, Mice, Heme Oxygenase-1, Membrane Potential, Mitochondrial
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