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Cited by 255

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

In Vitro Structural and Functional Evaluation of Gold Nanoparticles Conjugated Antibiotics

Open access
Saha, Biswarup, Bhattacharya, Jaydeep, Mukherjee, Ananda, Ghosh, AnupKumar, Santra, ChittaRanjan, Dasgupta, Anjan K, Karmakar, Parimal·2007·Nanoscale Research Letters
DOI 10.1007/s11671-007-9104-2
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Abstract

Bactericidal efficacy of gold nanoparticles conjugated with ampicillin, streptomycin and kanamycin were evaluated. Gold nanoparticles (Gnps) were conjugated with the antibiotics during the synthesis of nanoparticles utilizing the combined reducing property of antibiotics and sodium borohydride. The conjugation of nanoparticles was confirmed by dynamic light scattering (DLS) and electron microscopic (EM) studies. Such Gnps conjugated antibiotics showed greater bactericidal activity in standard agar well diffusion assay. The minimal inhibitory concentration (MIC) values of all the three antibiotics along with their Gnps conjugated forms were determined in three bacterial strains,Escherichia coli DH5α,Micrococcus luteus and Staphylococcus aureus. Among them, streptomycin and kanamycin showed significant reduction in MIC values in their Gnps conjugated form whereas; Gnps conjugated ampicillin showed slight decrement in the MIC value compared to its free form. On the other hand, all of them showed more heat stability in their Gnps conjugated forms. Thus, our findings indicated that Gnps conjugated antibiotics are more efficient and might have significant therapeutic implications.

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Metadata

Authors
Saha, B., Bhattacharya, J., Mukherjee, A., Ghosh, A., Santra, C., Dasgupta, A. K., & Karmakar, P.
Venue
Nanoscale Research Letters
Publisher
Springer Science and Business Media LLC
Published
2007-11-17
Volume
2
Issue
12
ISSN
1556-276X (ISSN-L)
DOI
10.1007/s11671-007-9104-2
OpenAlex
W2139522201
Cited by
255
References
22
FWCI
2.38
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: In Vitro Structural and Functional Evaluation of Gold Nanoparticles Conjugated Antibiotics. https://app.cochat.ai/papers/10.1007/s11671-007-9104-2
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Saha, B., Bhattacharya, J., Mukherjee, A., Ghosh, A., Santra, C., Dasgupta, A. K., & Karmakar, P. (2007). In Vitro Structural and Functional Evaluation of Gold Nanoparticles Conjugated Antibiotics. Nanoscale Research Letters. https://doi.org/10.1007/s11671-007-9104-2

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