Glutamate System Genes Associated with Ventral Prefrontal and Thalamic Volume in Pediatric Obsessive-Compulsive Disorder
Open accessAbstract
This pilot study was undertaken to determine if there was a significant association between specific glutamate system genes and regional volumes of interest implicated in the pathogenesis of obsessive-compulsive disorder (OCD). Volumetric magnetic resonance imaging (MRI) and genotyping of 7 polymorphisms in two genes, glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and solute linked carrier, family 1, member 1 (SLC1A1) were conducted in 31 psychotropic-naïve pediatric OCD patients. The rs1805476 variant of GRIN2B was associated with left but not right orbital frontal cortex (OFC) (p=0.04) and right but not left anterior cingulate cortex (ACC) volume (p=0.02). The SLC1A1 rs3056 variant was associated with increased total (p=0.01), left (p=0.02) and right (p=0.02) thalamic volume. These results suggest that GRIN2B and SLC1A1 may be associated with regional volumetric alterations in OFC, ACC, and thalamus in children with OCD.
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SLC1A1 rs3056 variant is associated with increased total, left, and right thalamic volume in OCD.
“SLC1A1 rs3056 variant could be shown to be associated with increased total, left, and right thalamic volume in OCD (Arnold et al. 2009).”
From The neurobiological link between OCD and ADHD (2014) · cites this paper as Arnold et al. 2009
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References 72 · Cited by 46
Research works printed but not linked: 1
- Arnold PD 2007 Glutamate genes in obsessive-compulsive disorder including childhood onset cases and neuroimaging PhD dissertation University of Toronto Toronto
- Authors
- Arnold, P. D., MacMaster, F. P., Hanna, G. L., Richter, M. A., Sicard, T., Burroughs, E., Mirza, Y., Easter, P. C., Rose, M., Kennedy, J. L., & Rosenberg, D. R.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Wayne State University (US)
- University of Michigan (US)
- Corresponding author
- Arnold, Paul Daniel
- ORCID
- Venue
- Brain Imaging and Behavior
- Published
- 2008-10-22
- Volume
- 3
- Issue
- 1
- Pages
- 64-76
- ISSN
- 1931-7557 (ISSN-L)
- 1931-7565
- PMC
- PMC2964163
- OpenAlex
- W1973140386
- Cited by
- 46
- References
- 72
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 3 · 2020: 4 · 2019: 5 · 2018: 2 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Imaging and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K24MH002037, R01MH085300, R01MH059299)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- pediatric obsessive-compulsive disorder, NR2B subunit, SLC1A1, glutamate receptors, thalamic volume, orbitofrontal cortex, anterior cingulate cortex, brain volume, genetic polymorphism, neuroimaging genetics
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